Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse.
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Summary
The present data support the active role in NOD mice of a thymus-derived CD4+ subset that controls peripheral pathogenic autoimmune effectors.
- Type
- article
- Published
- 1998-09-01
- Cited by
- 144
- References
- 58
- OpenAlex
- https://openalex.org/W1498917551
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45947527
Keywords
Nod, Thymocyte, CD8, T-cell receptor, NOD mice
References
- Studies on the mechanism of suppression of experimental allergic encephalomyelitis induced by myelin basic protein-cell conjugates.
- Experimental allergic encephalomyelitis in the Lewis rat. A model of predictable relapse by cyclophosphamide.
- Neonatal injection of CD3 antibody into nonobese diabetic mice reduces the incidence of insulitis and diabetes.
- Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes.
- Endogenous granulocyte-macrophage colony-stimulating factor is involved in IL-1- and IL-7-induced murine thymocyte proliferation.
- Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.
- Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.
- A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice.
- NK1.1+ CD4+ CD8‐ thymocytes with specific lymphokine secretion
- Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.
- Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells
- Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules
- Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines.
- Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus
- In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice.
- High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.
- Lack of L‐selectin expression by cells transferring diabetes in NOD mice: insights into the mechanisms involved in diabetes prevention by Mel‐14 antibody treatment
- Effect of adjuvant therapy on development of diabetes in mouse and man.
- The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males.
- Role of NK1.1+ T Cells in a TH2 Response and in Immunoglobulin E Production
Cited by
- The use of CD3-specific antibodies in autoimmune diabetes: a step toward the induction of immune tolerance in the clinic.
- Control of autoreactive T cell activation by immunoregulatory T cells (ART).
- Migration rules: functional properties of naive and effector/memory-like regulatory T cell subsets.
- Autoimmune polyendocrine syndrome type I. Novel diagnostic assays and immune regulation
- Modulation de la réponse immunitaire par TLR7: rôle dans le diabète de type 1 et l'asthme allergique.
- Selectin-mediated leukocyte trafficking during the development of autoimmune disease.
- Control of autoimmunity by naturally arising regulatory CD4+ T cells.
- Immunotherapy of type 1 diabetes mellitus.
- Effectors and regulators of cellular immune response in autoimmune liver disease
- The pathogenesis of diabetes in the NOD mouse.
- Nonmitogenic CD3 Antibody Reverses Virally Induced (Rat Insulin Promoter-Lymphocytic Choriomeningitis Virus) Autoimmune Diabetes Without Impeding Viral Clearance1
- Infections That Induce Autoimmune Diabetes in BBDR Rats Modulate CD4+CD25+ T Cell Populations12
- Role of regulatory T cells in the pathogenesis of autoimmune diabetes.
- Increasing Donor Chimerism and Inducing Tolerance to Islet Allografts by Post‐Transplant Donor Lymphocyte Infusion
- Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment1
- Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes
- Oral tolerance: mechanisms and therapeutic applications.
- Regulatory T cells in the control of immune pathology
- Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis1
- Regulatory T‐cell physiology and application to treat autoimmunity
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