Cancer Genome Landscapes
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Summary
This work has revealed the genomic landscapes of common forms of human cancer, which consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of "hills" (Genes altered infrequently).
- Type
- review
- Published
- 2013-03-29
- Cited by
- 7,267
- References
- 184
- Access
- Open access
- OpenAlex
- https://openalex.org/W2044433401
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1941979
Keywords
Genome, Gene, Carcinogenesis, Biology, Cancer
References
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- IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A
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- The DNA damage response: putting checkpoints in perspective
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- Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
- Accumulation of driver and passenger mutations during tumor progression
- Advances in understanding cancer genomes through second-generation sequencing
- Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
- The clonal evolution of tumor cell populations.
- Epidermal growth factor receptor mutations in lung cancer
- Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
- Analysis of the Coding Genome of Diffuse Large B-Cell Lymphoma
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
- ERBB receptors and cancer: the complexity of targeted inhibitors
- Kinase requirements in human cells: I. Comparing kinase requirements across various cell types
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- Rapid learning: a breakthrough agenda.
- The Detection of the Methylated Wif-1 Gene Is More Accurate than a Fecal Occult Blood Test for Colorectal Cancer Screening
- ContrastRank: a new method for ranking putative cancer driver genes and classification of tumor samples
- Challenges and opportunities for next-generation sequencing in companion diagnostics
- Emerging biomarkers in head and neck cancer in the era of genomics
- Integration of Genomic Data Enables Selective Discovery of Breast Cancer Drivers
- Mutations of epigenetic regulatory genes are common in thymic carcinomas
- Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems.
- Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies
- Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis
- Frequency and distribution of Notch mutations in tumor cell lines
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- RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
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- Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity
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