Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
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Summary
It is reported that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction than in controls, especially among subjects with low body-mass index and low plasma levels of ApoB.
- Type
- article
- Published
- 1992-10-01
- Cited by
- 2,069
- References
- 21
- OpenAlex
- https://openalex.org/W2043600435
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4352241
Keywords
Myocardial infarction, Internal medicine, Angiotensin-converting enzyme, Bradykinin, Genotype
References
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- Mechanism of Coronary Vasodilation Produced by Bradykinin
- Ramiprilat Enhances Endothelial Autacoid Formation by Inhibiting Breakdown of Endothelium‐Derived Bradykinin
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Cited by
- Vascular renin-angiotensin-system, endothelial function and atherosclerosis?
- Genetic determinants of myocardial infarction.
- Enhanced predictability of myocardial infarction in Japanese by combined genotype analysis.
- Evaluation of the postinfarct patient.
- Angiotensin-converting enzyme in human skeletal muscle. A simple in vitro assay of activity in needle biopsy specimens.
- Disordered eicosanoid formation in pregnancy-induced hypertension.
- Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension.
- Deletion polymorphism in the angiotensin I converting enzyme (ACE) gene as a genetic risk factor for sarcoidosis.
- Lack of association of the angiotensin converting enzyme polymorphism with essential hypertension in a Chinese population.
- Angiotensin-converting enzyme (ACE) gene polymorphisms in patients characterised by coronary angiography
- Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide.
- Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease.
- Measurement of patient compliance.
- LOX-1, a possible clue to the missing link between hypertension and atherogenesis.
- Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of heart failure caused by left ventricular systolic dysfunction.
- Deletion polymorphism of the angiotensin converting enzyme gene is associated with an increase in left ventricular mass in men with type 2 diabetes mellitus.
- Angiotensin-converting enzyme gene polymorphism and geometric patterns of hypertensive left ventricular hypertrophy.
- Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene is not associated with restenosis after coronary stent placement.
- Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system.
- Angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism in hypertensive patients with different degrees of obstructive sleep apnea.
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