Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.
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Summary
Although H4-K20 methylation does not correlate with gene activity, it appears to be regulated during the cell cycle and is demonstrated to have an essential role in Drosophila development.
- Type
- article
- Published
- 2002-07-09
- Cited by
- 322
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W2042487483
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15504308
Keywords
Histone H4, Histone methyltransferase, EZH2, Biology, Histone methylation
References
- The FlyBase database of the Drosophila genome projects and community literature.
- Functional analysis of the chromo domain of HP1.
- Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
- The protein encoded by the Drosophila position‐effect variegation suppressor gene Su(var)3‐9 combines domains of antagonistic regulators of homeotic gene complexes.
- Studies of histone methylation during the HeLa S-3 cell cycle.
- Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
- Preparation of nucleosome core particle from recombinant histones.
- The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4
- The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
- Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus
- Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
- Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
- Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
- Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.
- SET domain proteins modulate chromatin domains in eu- and heterochromatin
- The language of covalent histone modifications
- Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena.
- Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
- Insertional mutagenesis of the Drosophila genome with single P elements.
- Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis.
Cited by
- Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
- PR-Set7 Establishes a Repressive trans-Tail Histone Code That Regulates Differentiation
- 53BP1: function and mechanisms of focal recruitment.
- A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases
- Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling
- The emerging role of lysine methyltransferase SETD8 in human diseases
- Generation and characterization of methyl-lysine histone antibodies.
- The epigenetic regulation of cell cycle and chromatin dynamic by sirtuins
- Regulation and function of H3K9 methylation.
- Investigating the cell cycle-associated dynamics of histone modifications using quantitative mass spectrometry.
- Purification of histone methyltransferases from HeLa cells.
- Genetic and cytological analysis of Drosophila chromatin-remodeling factors.
- Integrating chromatin structure and global chromosome dynamics
- [The biological functions of lysine methyltransferase PR-SET7].
- Functional analysis of the histone methyltransferase SET9 in androgen receptor regulation and prostate cancer
- Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain
- In vitro histone demethylase assays.
- 6 Structure of SET domain protein lysine methyltransferases.
- 5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function.
- Histone Demethylases and Cancer
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