Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

Keywords

Cytochrome c, Biology, Caspase, Apoptosis, Cytosol

References

• Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.José Aguilar Jurado — 1998
• An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9*Hua Zou, Yuchen Li, Xuesong Liu — 1999
• The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.Junying Yuan, H. Robert Horvitz — 1992
• The Bcl-2 protein family: arbiters of cell survival.Jerry M. Adams, Suzanne Cory — 1998
• Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c.Mohanish Deshmukh, Eugene M. Johnson — 1998
• Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedJie Yang, Xuesong Liu, Kapil N. Bhalla — 1997
• Cell-specific Induction of Apoptosis by Microinjection of Cytochrome cFeng Li, Anu Srinivasan, Yu Wang — 1997
• Genetic control of programmed cell death in Drosophila.Kristin White, Megan E. Grether, John Abrams — 1994
• Apoptosis Induced by Drosophila Reaper and Grim in a Human SystemJustin V. McCarthy, Vishva M. Dixit — 1998
• Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.Anthony G. Uren, M Pakusch, Christine J. Hawkins — 1996
• The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.Mike Rothe, Ming-Gui Pan, William J. Henzel — 1995
• Common Principles of Protein Translocation Across MembranesGottfried Schatz, Bernhard Dobberstein — 1996
• The head involution defective gene of Drosophila melanogaster functions in programmed cell death.Megan E. Grether, John Abrams, Julie Agapite — 1995
• Drosophila p53 binds a damage response element at the reaper locus.Michael H. Brodsky, William Nordstrom, Garson Tsang — 2000
• A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases*Ryōsuke Takahashi, Quinn L. Deveraux, Ingo Tamm — 1998
• STOICHIOMETRY, FREE ENERGY, AND KINETIC ASPECTS OF CYTOCHROME C : APAF-1 BINDING IN APOPTOSISCherie B. Purring, Hua Zou, Xiaodong Wang — 1999
• Caspases: enemies within.Nancy A. Thornberry, Yuri Lazebnik — 1998
• Cytochrome c: can't live with it--can't live without it.John C. Reed — 1997
• IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspasesQuinn L. Deveraux, Natalie Roy, Henning R. Stennicke — 1998
• The Bcl-2 protein family.Bruno Antonsson, Jean‐Claude Martinou — 2000

Cited by

• New insights in mitochondrial calcium handling by sodium/calcium exchanger.Antonella Scorziello, Claudia Savoia, Agnese Secondo — 2013
• Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signallingAndreas Gewies — 2004
• XIAP: Apoptotic brake and promising therapeutic targetMartin Holčı́k, Hilary D. F. Gibson, Robert G. Korneluk — 2001
• Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer CellsAsligul Yalcin-Chin — 2008
• Hsp70: anti-apoptotic and tumorigenic protein.Anne-Laure Rérole, Gaëtan Jégo, Carmen Garrido — 2011
• Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expressionAmjad Ali — 2001
• Viral proteins and the mitochondrial apoptotic checkpoint.Philip J. Bos — 2001
• The Survivin saga goes in vivo.Ying Zhu — 2001
• HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*Anne M. Verhagen, John Silke, Paul G. Ekert — 2002
• Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy.Nuria Verde — 2001
• Apoptosis and Its Relevance in Cancer TherapyJan E. Ehlert, Michael H.G. Kubbutat — 2001
• Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ *Micha Brumlik — 2002
• Mouse Uterine Epithelial Apoptosis Is Associated with Expression of Mitochondrial Voltage-Dependent Anion Channels, Release of Cytochrome C from Mitochondria, and the Ratio of Bax to Bcl-2 or Bcl-X1Susan Schoubben-Heisk — 2003
• Role of inherited defects decreasing Fas function in autoimmunity.López Gómez, José Manuel — 2003
• The Polypeptide Chain-releasing Factor GSPT1/eRF3 Is Proteolytically Processed into an IAP-binding Protein*嘉彦 岡崎, 朋和 高橋, 文夫 松前 — 2003
• Alterations in the apoptotic machinery and their potential role in anticancer drug resistanceGabriel Anaya Duarte — 2003
• The Bcl-2 family: roles in cell survival and oncogenesisEnric Marco Granell — 2003
• Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy.José Antonio Azpiazu, Xabier Elorza Maiztegi — 2004
• IRES in distress: translational regulation of the inhibitor of apoptosis proteins XIAP and HIAP2 during cell stressMariana Tessarioli — 2005
• Clinical treatments for mitochondrial dysfunctions after brain injuryGianmaria Tavernar — 2006

Related papers

• Integrity of XIAP is essential for effective activity recovery of apoptosome and its downstream caspases by Smac/Diablo.Faezeh Attaran-Bandarabadi, Behnaz Ahangarian Abhari, Shima Hallaj Neishabouri — 2017
• Gold opens mitochondrial pathways to apoptosisMark J. McKeage — 2002
• Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia.Stefan Schliep, Thomas Decker, Folker Schneller — 2004
• Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway*Srinivasa M. Srinivasula, Pinaki Datta, Xuejun Fan — 2000
• XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosisShawn B. Bratton, Jennifer A. Lewis, Michael Butterworth — 2002
• Initiator caspases in apoptosis signaling pathwaysMin Chen, Jin Wang — 2002
• Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases.Birgit Zech, Roman Köhl, Andreas von Knethen — 2003
• Splitting the ApoptosomeAndrew Tri Van Ho, Eldad Zacksenhaus — 2004
• Transforming growth factor-beta(1) induces apoptosis in rat FaO hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex.Caroline Freathy, David G. Brown, Ruth Roberts — 2000
• Alpha‐fetoprotein antagonizes X‐linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP–caspase interactionElena Dudich, Lidia Semenkova, I.V. Dudich — 2006