The Bcl-2 protein family: arbiters of cell survival.
Explore this paper's citation graph
Summary
Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens.
- Type
- review
- Published
- 1998-08-28
- Cited by
- 5,621
- References
- 110
- OpenAlex
- https://openalex.org/W1964617786
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39374999
Keywords
Cell biology, Apoptosis, Caspase, Proteases, Biology
References
- Genetic control of programmed cell death in the nematode C. elegans.
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.
- The cell death inhibitor Bcl‐2 and its homologues influence control of cell cycle entry.
- A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.
- A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.
- Bax alpha perturbs T cell development and affects cell cycle entry of T cells.
- Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.
- Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.
- Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.
- Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer.
- Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.
- Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.
- Molecular thanatopsis: a discourse on the BCL2 family and cell death.
- Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus.
- Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation.
- Double identity for proteins of the Bcl-2 family
- Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K
- Bcl2 is the guardian of microtubule integrity.
- bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.
Cited by
- La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse
- GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
- Primary peritoneal low-grade serous carcinoma forming a mass in the colon mimicking a colonic primary carcinoma: a case report.
- Molecular pathogenesis of MALT lymphoma
- The Roles of Reelin, Bcl2, and Serotonin in Cerebellar Pathology in Autism
- Biophysical Insights into the Oligomerization of Bclxl Apoptotic Repressor
- Antivirale Immunantwort und Virus-induzierte Apoptose von Insulin-produzierenden Zellen in der Pathogenese des Typ 1 Diabetes
- Signal transduction and apoptosis pathways as therapeutic targets.
- Programmed Cell Death in C. elegans
- Dimerization of two novel apoptosisinducing proteins and its function in regulating cell apoptosis
- Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases.
- A Novel BH3-like Domain in BID Is Required for Intramolecular Interaction and Autoinhibition of Pro-apoptotic Activity*
- Mitochondria at the Crossroad of Apoptotic Cell Death
- Apoptosis: A Two‐edged Sword in Aging
- The Molecular Mechanism of Programmed Cell Death in C. elegans
- Cell Division Regulation by BIR1, a Member of the Inhibitor of Apoptosis Family in Yeast*
- Phosphorylation of Bcl-2 Protein by CDC2 Kinase during G2/M Phases and Its Role in Cell Cycle Regulation*
- Cleavage of Bax enhances its cell death function.
- MCL-1S, a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1, Encodes a Proapoptotic Protein Possessing Only the BH3 Domain*
- Gustatory innervation and bax‐dependent Caspase‐2: Participants in the life and death pathways of mouse taste receptor cells
Related papers
- Plant phytaspases and animal caspases: structurally unrelated death proteases with a common role and specificity.
- Caspase-like proteases and their role in programmed cell death in plants
- Sequential Activation of Caspases and Serine Proteases (Serpases) During Apoptosis
- Plant life needs cell death, but does plant cell death need Cys proteases?
- Determination of Caspase-Like Activities in Roots by the Use of Fluorogenic Substrates.
- Protease signalling in cell death: caspases versus cysteine cathepsins
- Phytaspases: Aspartate-specific proteases involved in plant cell death
- Caspase-like proteases regulate aluminum-induced programmed cell death in peanut