Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ *
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Summary
It is demonstrated that inhibition of IAP proteins can modulate the efficacy of antineoplastic agents and enhanced drug-induced caspase action in situ.
- Type
- article
- Published
- 2002-11-15
- Cited by
- 269
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W12218061
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33682690
Keywords
Philosophy, Humanities, Political science, Sociology
References
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- NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
- An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs
- Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat
- sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
- Drosophila sickle is a novel grim-reaper cell death activator.
- A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
- Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
Cited by
- Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
- Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
- Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
- Overcoming resistance to apoptosis in cancer therapy.
- The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
- Cell penetrating peptides can exert biological activity: a review
- Therapy-induced apoptosis in primary tumors.
- Mimicry of protein function with cell-penetrating peptides.
- Effect of Smac on TRAIL-induced apoptosis of prostate cancer cell line PC-3 and the molecular mechanism
- Stress Response Pathways in Cancer
- Pro-apoptotic Peptide Amphiphile Self-assembled with the Assistance of Polycations
- Epigenetic regulation of the TRAIL/Apo2L apoptotic pathway by histone deacetylase inhibitors: an attractive approach to bypass melanoma immunotherapy resistance.
- E2F1 induction following DNA damage and oncogene activation
- Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model.
- c-ABL AND ARG DRIVE CANCER CHEMORESISTANCE VIA ACTIVATION OF MULTIPLE SIGNALING PATHWAYS
- SMAC is expressed de novo in a subset of cervical cancer tumors
- Apoptotic pathways and therapy resistance in human malignancies.
- Apoptotic signaling in lung carcinoma cells : With focus on mechanisms of radioresistance
- Regulation of Mitochondria-dependent Apoptosis in Non-Small Cell Lung Cancer: Implications for Cancer Therapy
- IAP antagonization promotes inflammatory destruction of vasculature endothelium and inhibits tumor growth
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