The Nuclear Epidermal Growth Factor Receptor Signaling Network and its Role in Cancer
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Summary
The current knowledge of the nuclear EGFR signaling network is summarized, including how it is trafficked to the nucleus, the functions it serves in the nucleus, and how these functions impact cancer progression, survival and response to chemotherapeutics.
- Type
- review
- Published
- 2011-11-01
- Cited by
- 223
- References
- 81
- Access
- Open access
- OpenAlex
- https://openalex.org/W1508835219
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36325702
Keywords
Epidermal growth factor receptor, Cancer research, Cetuximab, Erlotinib, Gefitinib
References
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- Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase*
- SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor
- EGFR Nuclear Import in Gallbladder Carcinoma: Nuclear Phosphorylated EGFR Upregulates iNOS Expression and Confers Independent Prognostic Impact
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- Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
- Nuclear EGFR Contributes to Acquired Resistance to Cetuximab
- Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation.
Cited by
- G protein–coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor–promoted centrosomal separation
- Activation of EGFR Signaling from Pilocytic Astrocytomas to Glioblastomas
- The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer
- FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation
- Epidermal growth factor receptor and ligand family expression and activity in glioblastoma
- Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma.
- Identification of novel inflammatory serum biomarker signatures associated with pancreatic cancer and molecular characterization of antitumour agents over proliferation and apoptosos in vitro
- Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.
- IGFBP2 POTENTIATES EGFR-STAT3 SIGNALING IN GLIOMA
- Targeting the calmodulin-regulated ErbB/Grb7 signaling axis in cancer therapy.
- Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells
- Pediatric neuro‐oncology: Current status and future directions
- Nuclear localization of epidermal growth factor receptor (EGFR) in ameloblastomas
- Insulin-Like Growth Factor and Epidermal Growth Factor Signaling in Breast Cancer Cell Growth: Focus on Endocrine Resistant Disease
- Downregulation of CD9 promotes pancreatic cancer growth and metastasis through upregulation of epidermal growth factor on the cell surface.
- Smad7 Modulates Epidermal Growth Factor Receptor Turnover through Sequestration of c-Cbl
- EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1
- Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors
- Correlation study and significance of the EGFR expression in serum, lymph nodes and tumor tissue of NSCLC
- Receptor tyrosine kinase structure and function in health and disease
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