Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF
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Summary
It is shown that nuclear IGF1R associates with the transcription factor LEF1 and increases promoter activity of LEF 1 downstream target genes cyclin D1 and axin2, suggesting a novel function for IGF1r.
- Type
- article
- Published
- 2012-01-20
- Cited by
- 84
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W2003340108
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:783282
Keywords
Insulin-like growth factor 1 receptor, Transcription factor, Enhancer, Biology, Cell biology
References
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- A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
- Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors
- Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System (*)
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- Insulin and insulin-like growth factor signalling in neoplasia
- Type 1 IGF receptor translocates to the nucleus of human tumor cells
- Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
- The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.
Cited by
- FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation
- The Nucleus-Localized Epidermal Growth Factor Receptor Is SUMOylated.
- Análise da expressão e do silenciamento do receptor tipo 1 do fator de crescimento semelhante à insulina em tumores adrenocorticais humanos
- Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
- Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment
- Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor Distribution.
- Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas
- Sodium Arsenite Represses the Expression of Myogenin in C2C12 Mouse Myoblast Cells Through Histone Modifications and Altered Expression of Ezh2, Glp, and Igf-1
- Nuclear translocation of IGF-1R via p150Glued and an importin-β/RanBP2-dependent pathway in cancer cells
- The LIF-Mediated Molecular Signature Regulating Murine Embryo Implantation1
- Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.
- Insulin/Insulin-Like Growth Factors in Cancer: New Roles for the Aryl Hydrocarbon Receptor, Tumor Resistance Mechanisms, and New Blocking Strategies
- Tissue factor/factor VIIa induces cell survival and gene transcription by transactivation of the insulin-like growth factor 1 receptor
- Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways
- From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells
- Nuclear translocation of fibroblast growth factor receptor 3 and its significance in pancreatic cancer.
- Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein
- The Multifaceted Actions of Leukaemia Inhibitory Factor in Mediating Uterine Receptivity and Embryo Implantation
- Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
- Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy
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