Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF

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Summary

It is shown that nuclear IGF1R associates with the transcription factor LEF1 and increases promoter activity of LEF 1 downstream target genes cyclin D1 and axin2, suggesting a novel function for IGF1r.

Type
article
Published
2012-01-20
Cited by
84
References
28
Access
Open access

Keywords

Insulin-like growth factor 1 receptor, Transcription factor, Enhancer, Biology, Cell biology

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