Differential Characteristics of Cytotoxic T Lymphocytes Restricted by the Protective HLA Alleles B*27 and B*57 in HIV-1 Infection
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Summary
The data show that many of the mechanisms of CTL that are generally held responsible for slowing down HIV-1 disease progression hold for HLA-B*57 but do not hold forHLA- B*27, and the CTL response restricted by nonprotective HLA alleles was significantly higher and broader, and of higher affinity than in individuals expressing these alleles without HLA*27.
- Type
- article
- Published
- 2014-11-01
- Cited by
- 4
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2040957293
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5408697
Keywords
CTL*, Immunodominance, Biology, Cytotoxic T cell, Immunology
References
- Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells
- Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.
- Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
- Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS.
- Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control
- AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
- High responsiveness of HLA‐B57‐restricted Gag‐specific CD8+ T cells in vitro may contribute to the protective effect of HLA‐B57 in HIV‐infection
- Modeling the MHC class I pathway by combining predictions of proteasomal cleavage,TAP transport and MHC class I binding
- Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations.
- Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
- Weak anti-HIV CD8(+) T-cell effector activity in HIV primary infection.
- Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
- Isolation and propagation of HIV-1 on peripheral blood mononuclear cells
- Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype
- Rapid Antigen Processing and Presentation of a Protective and Immunodominant HLA-B*27-restricted Hepatitis C Virus-specific CD8+ T-cell Epitope
- Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control
- Escape from highly effective public CD8+ T-cell clonotypes by HIV.
- HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity
- HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1
Cited by
- Cytotoxic T lymphocyte immunodominance to Epstein-Barr virus infection
- Mechanisms and Factors That Drive Extensive Human Immunodeficiency Virus Type-1 Hypervariability: An Overview
- Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection
- MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals
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