Immunodominance of an Antiviral Cytotoxic T Cell Response Is Shaped by the Kinetics of Viral Protein Expression1
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Summary
It is proposed that CTL against early viral proteins swiftly interfere with virus replication, resulting in efficient protection and the observed absence of early CTL in persistent infections might not be the cause, but rather the consequence of viral persistence.
- Type
- article
- Published
- 2003-11-15
- Cited by
- 128
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1951894072
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42792616
Keywords
CTL*, Immunodominance, Lymphocytic choriomeningitis, Viral load, Virology
References
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- The virology and immunobiology of lymphocytic choriomeningitis virus infection.
- Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
- Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
- Endogenous generation and presentation of the ovalbumin peptide/Kb complex to T cells.
- Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules.
- Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
- Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice
- Evolution of the T Cell Repertoire During Primary, Memory, and Recall Responses to Viral Infection1
- Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
- Enumeration of antigen-presenting cells in mice infected with Sendai virus.
- Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.
- The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.
- Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection.
- Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates.
- Peptides naturally presented by MHC class I molecules.
- A kinetic basis for T cell receptor repertoire selection during an immune response.
- The major substrates for TAP in vivo are derived from newly synthesized proteins
- The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
- Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones.
Cited by
- Nucleoprotein‐specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcγR
- Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape
- Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation
- Generierung und Charakterisierung von spezifischen T-Zell-Antworten gegen Pilz- und Tumorantigene
- The influence of immunoproteasomes on T cell expansion during an antiviral immune response
- The regulation of CD8 T cell responses by inflammatory cytokines and FcgammaRIIB
- The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation
- The role of ubiquitin, heat shock proteins, and inducible proteasome subunits in major histocompatibility class I antigen presentation
- Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses1
- Absence of CTL Responses to Early Viral Antigens Facilitates Viral Persistence1
- SARS Immunity and Vaccination.
- Derivation and Fluidity of Acutely Induced Dysfunctional CD8+ T Cells1
- Cross-Presentation of the Long-Lived Lymphocytic Choriomeningitis Virus Nucleoprotein Does Not Require Neosynthesis and Is Enhanced via Heat Shock Proteins1
- Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4+ T Cell Responses Directed against a Broad Range of Epitopes1
- The role of coronin 1 during cell mediated immune responses
- Altered CD8+ T cell immunodominance after vaccinia virus infection and the naïve repertoire in inbred and F1 mice
- MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines1
- Immunoproteasomes Down-Regulate Presentation of a Subdominant T Cell Epitope from Lymphocytic Choriomeningitis Virus1
- Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis
- Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope
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