Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control
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Summary
These results establish an effector function and mechanism that clearly segregate with immunologic control of HIV and demonstrate that lytic granule contents of memory cells are a critical determinant of cytotoxicity that must be induced for maximal per-cell killing capacity.
- Type
- article
- Published
- 2008-12-01
- Cited by
- 602
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2039473791
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40265043
Keywords
Lytic cycle, Biology, Cytotoxic T cell, Effector, Granzyme B
References
- Granzyme B Activity in Target Cells Detects Attack by Cytotoxic Lymphocytes
- Induction of Cytotoxic Granules in Human Memory CD8+ T Cell Subsets Requires Cell Cycle Progression1
- Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).
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- Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects
- New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT.
- PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
- Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
- Delivering the kiss of death
- Upregulation of PD-1 Expression on HIV-Specific CD8+ T Cells Leads to Reversible Immune Dysfunction
- CD8+ T cells from most HIV‐1‐infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses
- Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow.
- Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
- Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection
- Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4+ and CD8+ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection
- Advances in understanding immunologic control of HIV infection
- HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.
- Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
Cited by
- Pushing the frontiers of T-cell vaccines: accurate measurement of human T-cell responses
- CD8 T-Cells from Most HIV-Infected Patients Lack Ex Vivo HIV-Suppressive Capacity during Acute and Early Infection
- Different antigen processing activities in dendritic cells, macrophages and monocytes lead to uneven production of HIV epitopes and affect CTL recognition
- Reactivation Kinetics of HIV-1 and Susceptibility of Reactivated Latently Infected CD4+ T Cells to HIV-1-Specific CD8+ T Cells
- Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses
- Enhancing T-cell responses to vaccination of HIV-1 infected subjects on antiretroviral therapy
- The role of CD4+ T cells in Friend virus infection
- Approaches towards avoiding lifelong antiretroviral therapy in paediatric HIV infection.
- Exploring the complexity of functional hiv-1 specific t-cell responses and global virus-host genetic variability
- Activation and memory differentiation of total and HIV-specific T cells that associate with viral control during subtype C HIV-1 infection
- Etude de l’établissement des réservoirs VIH lors de la primo-infection et de l’impact des traitements antirétroviraux très précoces sur ces réservoirs
- Mécanismes moléculaires de la réplication préférentielle du VIH-1 dans les cellules à polarisation Th1Th17 versus Th1 : rôle de PPARG dans la régulation négative de la réplication virale
- Association entre les dérégulations des cellules dendritiques et les altérations des lymphocytes B présentes chez les patients infectés par le VIH
- Parâmetros imunovirológicos em pacientes infectados pelo HIV, tratados ou não com antirretrovirais
- Inflammation chronique et hyperactivation du système immunitaire chez les patients HIV controllers : liens avec le contrôle antiviral et la mise en jeu de la voie des interférons
- HLA-B51 associated HIV-1 viral control
- Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers
- Residual viremia in patients on antiretroviral therapy incorporating nevirapine is not associated with the gag‐specific cellular immune response
- Regulation of T Cell Receptor Signaling by Diacylglycerol Kinases and Phosphatidylinositol Transfer Proteins
- Early Induction of Polyfunctional SIV-specific T Lymphocytes and Rapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys During Primary Infection
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