Induction of β-R1/I-TAC by Interferon-β Requires Catalytically Active TYK2*
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Summary
Catalytic TYK2 is the first identified component in an accessory signaling pathway that supplements ISGF3/interferon-stimulated response element signaling for gene induction by type I IFNs and indicates that the catalytic function of TYK 2 is required for IFN-β-mediated induction of β-R1.
- Type
- article
- Published
- 1999-01-22
- Cited by
- 33
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1576499008
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23766579
Keywords
Tyrosine kinase 2, Interferon, Biology, Cell biology, Signal transduction
References
- The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
- Phosphorylated interferon‐alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
- JAK2, a third member of the JAK family of protein tyrosine kinases.
- Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN‐alpha and IFN‐beta.
- The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN‐alpha signals.
- Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.
- p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.
- Differential Use of the βL Subunit of the Type I Interferon (IFN) Receptor Determines Signaling Specificity for IFNα2 and IFNβ*
- The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
- A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons
- The interferon system. A bird's eye view of its biochemistry.
- Different Relative Activities of Human Cell-Derived Interferon-α Subtypes: IFN-α8 Has Very High Antiviral Potency
- Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase
- Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.
- A protein tyrosine kinase in the interferon alpha/beta signaling pathway.
- Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase*
- The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).
- Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon- (*)
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
- Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities.
Cited by
- A New IFN-Like Cytokine, Limitin Modulates the Immune Response Without Influencing Thymocyte Development1
- Alternative and Accessory Pathways in the Regulation of IFN-β-Mediated Gene Expression
- Influenza A virus abrogates IFN‐γ response in respiratory epithelial cells by disruption of the Jak/Stat pathway
- Requirement of Catalytically Active Tyk2 and Accessory Signals for the Induction of TRAIL mRNA by IFN-β
- Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol.
- Complex modulation of cell type-specific signaling in response to type I interferons.
- Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.
- Cloning, genomic sequence, and chromosome mapping of Scyb11, the murine homologue of SCYB11 (alias βR1/H174/SCYB9B/I-TAC/IP-9/CXCL11)
- Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene.
- Importance of signaling via the IFN-α/β receptor on host cells for the realization of the therapeutic benefits of cyclophosphamide for mice bearing a large MOPC-315 tumor
- Tyrosine Phosphorylation of Protein Kinase D2 Mediates Ligand-inducible Elimination of the Type 1 Interferon Receptor*
- The Type I Interferon Receptor: Structure, Function, and Evolution of a Family Business
- TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo
- Pathogen Recognition Receptor Signaling Accelerates Phosphorylation-Dependent Degradation of IFNAR1
- A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors
- Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity – a tale of conflict and conundrum
- Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation
- Pharmacogenomics of responsiveness to interferon IFN‐β treatment in multiple sclerosis: A genetic screen of 100 type I interferon‐inducible genes
- Resistance to Interferons in Melanoma Cells Does Not Correlate with the Expression or Activation of Signal Transducer and Activator of Transcription 1 (Stat1)
- The role of IKKβ in interferon-γ-dependent signaling.
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