Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation.
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Summary
Improved survival correlated with the measurable appearance of progenitor-derived myeloid cells in the spleen and enhanced reconstitution of a tissue myeloids pool offers protection against lethal challenge with serious fungal and bacterial pathogens.
- Type
- article
- Published
- 2002-12-15
- Cited by
- 116
- References
- 44
- OpenAlex
- https://openalex.org/W2036672411
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14207835
Keywords
Progenitor cell, Haematopoiesis, Biology, Transplantation, Stem cell
References
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- Local and Systemic Therapy of Pseudomonas Septicemia in Burned Mice
- Animal models: usefulness for studies of fungal pathogenesis and drug efficacy in aspergillosis.
- Leucocyte transfusions from rhG‐CSF or prednisolone stimulated donors for treatment of severe infections in immunocompromised neutropenic patients
- RENEWED INTEREST IN GRANULOCYTE TRANSFUSION THERAPY
- High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts.
- Epidemiology of infections due to Pseudomonas aeruginosa.
- Flow cytometric identification of murine neutrophils and monocytes.
- Bioluminescent indicators in living mammals
- An eosinophil-dependent mechanism for the antitumor effect of interleukin-4.
- Clinical use of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in neutropenia associated with malignancy.
- Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice.
- Chemotherapy of Pseudomonas septicemia in burned mice.
Cited by
- Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation.
- Co-culture of cord blood CD34(+) cells with human BM mesenchymal stromal cells enhances short-term engraftment of cord blood cells in NOD/SCID mice.
- Regenerative Medicine 2006
- Cryopreserved Ex Vivo-Expanded Allogeneic Myeloid Progenitor Cell Product Protects Neutropenic Mice from a Lethal Fungal Infection
- Stem Cells: Biology, Transplantation, and Political Ethics1
- Lineage commitment and developmental plasticity in early lymphoid progenitor subsets.
- Technoreview: In vivo bioluminescence imaging for integrated studies of infection
- Advances in umbilical cord blood stem cell expansion and clinical translation.
- Noninvasive biophotonic imaging for studies of infectious disease
- Granulocyte transfusion: questions remain.
- Ectopic expression of the homeobox gene Cdx2 is the key transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia; a novel mechanism in AML
- Strategies to enhance T-cell reconstitution in immunocompromised patients
- Exogenous administration of immunomodulatory therapies in hematopoietic cell transplantation: an infectious diseases perspective
- Preclinical Development of a Bridging Therapy for Radiation Casualties: Appropriate for High Risk Personnel
- Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.
- The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor.
- Fungal infections in bone marrow transplant patients
- Advances in umbilical cord blood manipulation—from niche to bedside
- CCR7 impairs hematopoiesis after hematopoietic stem cell transplantation increasing susceptibility to invasive aspergillosis.
- The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.
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