Advances in umbilical cord blood stem cell expansion and clinical translation.
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Summary
It is underscore that early-acting cytokines alone can expand HSPC with short-term engraftment activity, but that robust expansion of HSPCs with long-termEngraftment necessitates the synergistic action of multiple HSC-expansion agonists.
- Type
- review
- Published
- 2015-07-01
- Cited by
- 117
- References
- 174
- Access
- Open access
- OpenAlex
- https://openalex.org/W1795643695
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46283603
Keywords
Homing (biology), Progenitor cell, Haematopoiesis, Stem cell, Transplantation
References
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- The murine stromal cell line AFT024 acts specifically on human CD34+CD38- progenitors to maintain primitive function and immunophenotype in vitro.
- Thrombopoietin mobilizes CD34+ cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis.
- Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: evidence for accessory cell involvement in expansion of immature CD34+CD38- cells.
- Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors.
- Cocultivation of umbilical cord blood CD34+ cells with retro-transduced hMSCs leads to effective amplification of long-term culture-initiating cells.
- Hematopoietic Stem Cell Protocols
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- Mesenchymal Stem Cells Secreting Angiopoietin-Like-5 Support Efficient Expansion of Human Hematopoietic Stem Cells Without Compromising Their Repopulating Potential
- Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
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- Cytokine manipulation of primitive human hematopoietic cell self-renewal.
- Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34(+) cells are functionally active in an ex vivo flow model of thrombosis.
- Ex vivo Expansion of Umbilical Cord Blood Stem Cells Using Different Combinations of Cytokines and Stromal Cells
Cited by
- Filling the void: allogeneic myeloid cells for transplantation
- VE-Cadherin and ACE Co-Expression Marks Highly Proliferative Hematopoietic Stem Cells in Human Embryonic Liver
- Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells
- Methods of ex vivo expansion of human cord blood cells: challenges, successes and clinical implications
- Bioengineering Hematopoietic Stem Cell Niche toward Regenerative Medicine.
- The human and murine hematopoietic stem cell niches: are they comparable?
- Isolation and proliferation of umbilical cord tissue derived mesenchymal stem cells for clinical applications
- Hematopoietic stem cell expansion and generation: the ways to make a breakthrough
- Optimization of production of anti-cancer vaccines based on dendritic cells
- Endothelial progenitor cells promote efficient ex vivo expansion of cord blood-derived hematopoietic stem/progenitor cells.
- Individualized conditioning regimes in cord blood transplantation: Towards improved and predictable safety and efficacy
- Cell Therapy for Prophylactic Tolerance in Immunoglobulin E-mediated Allergy
- Downregulation of heme oxygenase 1 (HO-1) activity in hematopoietic cells enhances their engraftment after transplantation
- Eltrombopag after allogeneic haematopoietic cell transplantation in a case of poor graft function and systematic review of the literature
- Cryobanking of aquatic species
- In Vitro Culture of Human Hematopoietic Stem Cells in Serum Free Medium and Their Monitoring by Flow Cytometry.
- Engineering Hematopoietic Stem Cells: Lessons from Development
- Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors
- Human umbilical cord blood hematopoietic stem cell expansion by the RNA-binding protein Musashi-2.
- Exploring Life Saving Potential of Umbilical Cord Blood Derived Hematopoietic Stem Cells
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