Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.
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Summary
Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival.
- Type
- article
- Published
- 1999-01-01
- Cited by
- 2,109
- References
- 28
- OpenAlex
- https://openalex.org/W2036650593
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23087319
Keywords
NMDA receptor, Glutamate receptor, Neurodegeneration, Neuroscience, Receptor
References
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Cited by
- Neurotoxizität von Allgemeinanästhetika im Kindesalter
- Effects of ketamine on the developing central nervous system.
- N-Methyl d-Aspartate Receptor-mediated Bidirectional Control of Extracellular Signal-regulated Kinase Activity in Cortical Neuronal Cultures*
- Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status
- Apoptosis in the in vivo mammalian forebrain.
- Long‐lasting synaptic modification in the rat hippocampus resulting from NMDA receptor blockade during development
- Activity‐dependent NMDA receptor‐mediated activation of protein kinase B/Akt in cortical neuronal cultures
- Drug‐induced Apoptotic Neurodegeneration in the Developing Brain
- The excitoprotective effect of N‐methyl‐d‐aspartate receptors is mediated by a brain‐derived neurotrophic factor autocrine loop in cultured hippocampal neurons
- General anesthetics and the developing brain: friends or foes?
- Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
- Web-based method for translating neurodevelopment from laboratory species to humans
- Anesthetic neurotoxicity in newborns: should we change clinical practice?
- The Role of Akt-GSK-3β Signaling and Synaptic Strength in Phencyclidine-Induced Neurodegeneration
- Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity
- RESEARCH ARTICLE: Clinical Anesthesia Causes Permanent Damage to the Fetal Guinea Pig Brain
- Neurologic birth defects after prenatal exposure to antiepileptic drugs
- Decreased glutathione levels and altered antioxidant defense in an animal model of schizophrenia: long-term effects of perinatal phencyclidine administration.
- Effect of ketamine administration on memory consolidation, p-CREB and c-fos expression in the hippocampal slices of minor rats
- Developmental GABAergic deficit enhances methamphetamine-induced apoptosis
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