Two for the Price of One: G Protein-Dependent and -Independent Functions of RGS6 In Vivo.
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Summary
Though efforts by multiple laboratories have contributed to the ever-growing RGS6 oeuvre, the pleiotropic nature of this gene will likely lead to additional work detailing the importance of R GS6 in neuropsychiatric disorders, cardiovascular disease, and cancer.
- Type
- review
- Published
- 2015-01-01
- Cited by
- 19
- References
- 125
- OpenAlex
- https://openalex.org/W900244749
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39552197
Keywords
Regulator of G protein signaling, Biology, Cell biology, Knockout mouse, Receptor
References
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- The Membrane Anchor R7BP Controls the Proteolytic Stability of the Striatal Specific RGS Protein, RGS9-2*♦
- Regulator of G Protein Signaling 6 (RGS6) Mediates Doxorubicin-induced ATM and p53 Activation by a Reactive Oxygen Species (ROS)-dependent Mechanism
- ATM Activation by Oxidative Stress
- A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer.
- Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
Cited by
- Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein*
- Activation of TIM1 induces colon cancer cell apoptosis via modulating Fas ligand expression.
- RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer
- Development of Bimolecular Luminescence Complementation Assay for RGS: G protein Interactions in Cells
- Regulation of G-protein coupled receptor signalling underpinning neurobiology of mood disorders and depression.
- Identification of small molecule inhibitors of regulator of G protein signaling proteins for pretherapeutic development for treatment of multiple pathologies
- Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials
- Probing the mutational landscape of regulators of G protein signaling proteins in cancer
- Path to drugging functional clones of luminal breast cancers using in-depth proteomics with spatially resolved mass spectrometry guided by MALDI imaging
- Path to Clonal Theranostics in Luminal Breast Cancers
- TIP60 buffers acute stress response and depressive behaviour by controlling PPARγ-mediated transcription.
- βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression
- Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum
- Function and regulation of RGS family members in solid tumours: a comprehensive review
- Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts
- Role of GPCR Signaling in Anthracycline-Induced Cardiotoxicity
- G-protein Signaling Regulating Opioid-induced Respiratory Rate Depression
- Atorvastatin Improves Cardiac Function in Diabetic Cardiomyopathy Rats
- Molecular cloning of a novel, nervous system-specific RGS6 isoform lacking canonical G protein regulatory effects and with dominant negative actions
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