Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.
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Summary
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).
- Type
- article
- Published
- 2004-06-25
- Cited by
- 3,973
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2036008499
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16181905
Keywords
Twist transcription factor, Biology, Metastasis, Cancer research, Epithelial–mesenchymal transition
References
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- Twist protein in mouse embryogenesis.
- twist is required in head mesenchyme for cranial neural tube morphogenesis.
- New functions for the matrix metalloproteinases in cancer progression
- Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer
- Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
- The pathogenesis of cancer metastasis
- An overview of epithelio-mesenchymal transformation.
- dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.
- DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
- Multiple ways of silencing E‐cadherin gene expression in lobular carcinoma of the breast
Cited by
- Effect of cancer on platelets.
- Advances in Cancer Stem Cell Biology
- Adherens junctions and cancer.
- Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant melanoma
- Genetic investigations of Saethre-Chotzen syndrome presenting with renal cell carcinoma.
- Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines.
- Regional lymph node metastases; a singular manifestation of the process of clinical metastases in cancer: contemporary animal research and clinical reports suggest unifying concepts.
- The H19 Non-Coding RNA Is Essential for Human Tumor Growth
- The role of the tumor microenvironment in metastasis studied by intravital imaging
- Stromal Myofibroblasts Accompany Modifications in the Epithelial Phenotype of Tongue Dysplastic and Malignant Lesions
- MicroRNAs in breast cancer
- Adherens junction: molecular architecture and regulation.
- TWIST1 Gene: First Insights in Felis catus
- Foxo3a Suppression of Urothelial Cancer Invasiveness through Twist1, Y-Box–Binding Protein 1, and E-Cadherin Regulation
- Immunotherapy of prostate cancer: should we be targeting stem cells and EMT?
- Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update
- Expression of Y-box-binding protein YB-1 allows stratification into long- and short-term survivors of head and neck cancer patients
- Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma
- Signaling from the Adherens Junction
- The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic sites
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