The role of iron and reactive oxygen species in cell death.
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Summary
The different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form ofIron-dependent cell death termed ferroptosis are described to suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.
- Type
- review
- Published
- 2014-01-01
- Cited by
- 2,149
- References
- 104
- OpenAlex
- https://openalex.org/W2011538447
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4843456
Keywords
Programmed cell death, Reactive oxygen species, Cell biology, Cell, Biology
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Cited by
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis*
- Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
- Design of Peptide-Based Probes for the Microscale Detection of Reactive Oxygen Species.
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma
- Characterization of Iron Response in Gynecological Cell Lines
- Bedeutung regulierter Zelltodprogramme für die Transplantation solider Organe
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis.
- Specifically designed peptide structures effectively suppressed oxidative reactions in chemical and cellular systems
- Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes
- Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells.
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- Redox interplay between mitochondria and peroxisomes
- Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
- Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death
- Targeted delivery of anti-cancer drugs by MS2 virus-like particles
- Metabolic Regulation and Coordination of the Metabolism in Bacteria in Response to a Variety of Growth Conditions.
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