Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.
Explore this paper's citation graph
Summary
Show that ephrin-B2, an Eph family transmembrane ligand, marks arterial but not venous endothelial cells from the onset of angiogenesis and suggest that reciprocal signaling between these two types of vessels is crucial for morphogenesis of the capillary beds.
- Type
- article
- Published
- 1998-05-29
- Cited by
- 1,790
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2035595755
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16656630
Keywords
Erythropoietin-producing hepatocellular (Eph) receptor, Biology, Ephrin, Angiogenesis, Anatomy
References
- Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.
- Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.
- The Atlas of Mouse Development
- Signaling Vascular Morphogenesis and Maintenance
- Mechanisms of angiogenesis
- On the development of the aortae, cardinal and umbilical veins, and the other blood vessels of vertebrate embryos from capillaries
- Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis.
- Multiple essential functions of neuregulin in development
- Requirement for neuregulin receptor erbB2 in neural and cardiac development
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
- The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells.
- neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia.
- Identification of a subpopulation of human renal microvascular endothelial cells with capacity to form capillary-like cord and tube structures
- Blood vessel formation: what is its molecular basis?
- Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
- Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.
- Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
- Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
Cited by
- ALK1 et BMP9 dans le remodelage vasculaire de la génétique humaine aux modèles murins
- Fibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in XenopusEmbryos
- EphB2 guides axons at the midline and is necessary for normal vestibular function.
- Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.
- Characterization of the human ephrin-A4 promoter.
- A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis.
- Human osteosarcoma expresses specific ephrin profiles
- Plumbing the mysteries of vascular development using the zebrafish.
- EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis
- Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium.
- Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.
- EphA4 regulates central nervous system vascular formation
- Sema3D and Sema7A have distinct expression patterns in chick embryonic development
- Activin receptor-like kinase 1 is essential for placental vascular development in mice
- KLF2 Transcription Factor Modulates Blood Vessel Maturation through Smooth Muscle Cell Migration*
- The Neurogenic Niche and Injury-Induced Neurogenesis.
- Arterial–Venous Specification During Development
- Ephrinb1 and Ephrinb2 Are Associated with Interleukin-7 Receptor α and Retard Its Internalization from the Cell Surface*
- The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells
- Therapeutic targeting of EPH receptors and their ligands
Related papers
- May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?
- Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer
- Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation
- Eph Receptors and Ephrins: Therapeutic Opportunities
- EPH/Ephrin-Targeting Treatment in Breast Cancer: A New Chapter in Breast Cancer Therapy
- Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis
- Up-regulations of EphB4, EphA2, EphB3 and Ephrin-A5 in NSCLCs and Their Clinical Significances(English)