Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer
Explore this paper's citation graph
Summary
It is shown for the first time that blocking expression of the Eph ligand Ephrin B3 inhibits NSCLC cell migration and invasion and calls for further studies on interference with Ephinus B3 as a possible therapeutic avenue in this tumor malignancy.
- Type
- article
- Published
- 2016-08-11
- Cited by
- 22
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2511710384
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27789467
Keywords
EPH receptor A2, Ephrin, Erythropoietin-producing hepatocellular (Eph) receptor, Cancer research, Biology
References
- Silencing of EphA2 inhibits invasion of human gastric cancer SGC-7901 cells in vitro and in vivo.
- Therapeutic targeting of EPH receptors and their ligands
- E-cadherin regulates the function of the EphA2 receptor tyrosine kinase.
- Mutated Ephrin Receptor Genes in Non‐Small Cell Lung Carcinoma and Their Occurrence with Driver Mutations—Targeted Resequencing Study on Formalin‐Fixed, Paraffin‐Embedded Tumor Material of 81 Patients
- Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor.
- The role of EPH receptors in cancer-related epithelial-mesenchymal transition
- Eph receptors and ephrins in cancer: bidirectional signaling and beyond
- A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo
- Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application.
- Crosstalk of the EphA2 Receptor with a Serine/Threonine Phosphatase Suppresses the Akt-mTORC1 Pathway in Cancer Cells
- Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism
- EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex
- Prognostic role of EphA2 in various human carcinomas: a meta-analysis of 23 related studies
- Management of non-small-cell lung cancer: recent developments.
- Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412
- Attenuation of Eph Receptor Kinase Activation in Cancer Cells by Coexpressed Ephrin Ligands
- Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer
- Activation of the EGFR Gene Target EphA2 Inhibits Epidermal Growth Factor–Induced Cancer Cell Motility
- Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung.
- EphA2 in the Early Pathogenesis and Progression of Non–Small Cell Lung Cancer
Cited by
- EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens
- Targeting Eph/ephrin system in cancer therapy.
- Heat stress induced, ligand-independent MET and EGFR signaling in hepatocellular carcinoma.
- Ephrin-B3 binds both cell-associated and secreted proteoglycans.
- Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers
- EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10
- Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
- EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells
- Multiplex immune protein profiling of fine‐needle aspirates from patients with non‐small‐cell lung cancer reveals signatures associated with PD‐L1 expression and tumor stage
- The Clinical Impact of the EPH/Ephrin System in Cancer: Unwinding the Thread
- Potential Therapeutic Value of Mangiferin for Lung Adenocarcinoma (Luad): A Comprehensive Study Based on in Vitro Experiments and Bioinformatics
- Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
- Host deficiency in ephrin-A1 inhibits breast cancer metastasis
- Eph and Ephrin Variants in Malaysian Neural Tube Defect Families
- YB‐1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2
- Signals transduced by Eph receptors and ephrin ligands converge on MAP kinase and AKT pathways in human cancers.
- May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?
- Targeting programmed cell death protein 1 (PD-1) for treatment of non-small-cell lung carcinoma (NSCLC); the recent advances.
- Eph Receptors and Ephrins in Cancer Progression
- Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer.
Related papers
- May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?
- Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation
- Roles of EphA1/A2 and ephrin‐A1 in cancer
- Eph Receptors and Ephrins: Therapeutic Opportunities
- EPH/Ephrin-Targeting Treatment in Breast Cancer: A New Chapter in Breast Cancer Therapy
- Up-regulations of EphB4, EphA2, EphB3 and Ephrin-A5 in NSCLCs and Their Clinical Significances(English)
- Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis