Reduced phosphodiesterase 3 activity and phosphodiesterase 3A level in synthetic vascular smooth muscle cells: implications for use of phosphodiesterase 3 inhibitors in cardiovascular tissues.
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Summary
It is demonstrated that a reduced PDE3/PDE4 activity ratio in synthetic VSMC correlates with a reducedPDE3 activity and is associated with marked reductions in PDE2A mRNA and protein levels, and this phenomenon associates with the phenotypic switch that occurs to VSMC in response to vascular damage.
- Type
- article
- Published
- 2002-05-01
- Cited by
- 38
- References
- 43
- OpenAlex
- https://openalex.org/W2033858438
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25957896
Keywords
Phosphodiesterase 3, Vascular smooth muscle, Phosphodiesterase, Biology, Internal medicine
References
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- Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney.
- Compartmentalization of cAMP Signaling in Mesangial Cells by Phosphodiesterase Isozymes PDE3 and PDE4 REGULATION OF SUPEROXIDATION AND MITOGENESIS*
- Cyclic AMP‐mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity
- Cell layer-specific expression of cyclic nucleotide phosphodiesterases in rat arteries: molecular cloning using isolated cell layers from paraformaldehyde-fixed tissues.
- Phosphorylation-mediated Activation and Translocation of the Cyclic AMP-specific Phosphodiesterase PDE4D3 by Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinases
- Cyclic Nucleotide Hydrolysis in Bovine Aortic Endothelial Cells in Culture: Differential Regulation in Cobblestone and Spindle Phenotypes
- Beta-adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: shifting the focus from inotropy to cyclic adenosine monophosphate.
- Effect of cilostazol on restenosis after coronary angioplasty and stenting in comparison to conventional coronary artery stenting with ticlopidine.
- Effects of cilostazol on angiographic restenosis after coronary stent placement.
- Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins.
- Nitroprusside enhances isoprenaline-induced increases in cAMP in rat aortic smooth muscle.
- Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model
Cited by
- Rôle des phophodiestérases dans la compartimentation subcellulaire de l'AMPc dans la cellule musculaire lisse vasculaire : étude des altérations dans l'insuffisance cardiaque
- Efficacy of Cilostazol a selective phosphodiesterase-3 inhibitor in rat model of Streptozotocin diabetes induced vascular dementia.
- Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system.
- Cyclic Nucleotide Phosphodiesterases (PDEs) in Smooth Muscle : Expression, Function and Mechanism
- PDE3A mutations cause autosomal dominant hypertension with brachydactyly
- Signaling Pathways That Control Rho Kinase Activity Maintain the Embryonic Epicardial Progenitor State
- Remote Microvascular Preconditioning Alters Specific Vasoactive Responses
- Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation.
- Vascular Smooth Muscle Cell Phenotype-Dependent Phosphodiesterase 4D Short Form Expression: Role of Differential Histone Acetylation on cAMP-Regulated Function
- Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
- Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo.
- PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
- Effect of Cilostazol on the P50 of the Oxygen-Hemoglobin Dissociation Curve
- β-Adrenergic cAMP Signals Are Predominantly Regulated by Phosphodiesterase Type 4 in Cultured Adult Rat Aortic Smooth Muscle Cells
- Clinical and molecular genetics of the phosphodiesterases (PDEs).
- Cardiovascular implications in the use of PDE5 inhibitor therapy
- Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway
- Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.
- Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
- Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system.
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