β-Adrenergic cAMP Signals Are Predominantly Regulated by Phosphodiesterase Type 4 in Cultured Adult Rat Aortic Smooth Muscle Cells
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Summary
This study underlines the importance of cAMP-PDEs in the dynamic control of intracellular cAMP signals in RASMCs, and demonstrates the prominent role of PDE4 in limiting β-AR responses.
- Type
- article
- Published
- 2012-10-18
- Cited by
- 19
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2038250633
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7955653
Keywords
Phosphodiesterase 3, IBMX, Phosphodiesterase, Endocrinology, Internal medicine
References
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- Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation*♦
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- Cyclic AMP‐mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity
- Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors
- PDEs create local domains of cAMP signaling.
- The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue.
- Effects of cyclic GMP elevation on isoprenaline‐induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3
- Monitoring of cAMP synthesis and degradation in living cells.
- Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases
- Regulation of differentiated properties and proliferation of arterial smooth muscle cells.
- Beta 3‐adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway
- Reduced phosphodiesterase 3 activity and phosphodiesterase 3A level in synthetic vascular smooth muscle cells: implications for use of phosphodiesterase 3 inhibitors in cardiovascular tissues.
- Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)*
- beta-adrenergic relaxation in pulmonary arteries: preservation of the endothelial nitric oxide-dependent beta2 component in pulmonary hypertension.
Cited by
- Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4
- The effects of artemisinin on the proliferation and apoptosis of vascular smooth muscle cells of rats
- Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms.
- Magnesium prevents β-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells.
- Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms
- Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective.
- RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice
- [Cyclic nucleotide phosphodiesterases: role in the heart and therapeutic perspectives].
- Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells.
- A study on the effect of β-adrenergic stimulation on the electrophysiology of the isolated heart
- Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder
- Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
- Cyclic nucleotide signalling compartmentation by PDEs in cultured vascular smooth muscle cells
- Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions.
- Dynamic FRET-FLIM based screening of signal transduction pathways
- PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective
- Dynamic FRET-FLIM based screens of signal transduction pathways: a feasibility study
- Developmental switch in immunolocalization of phosphodiesterase 7A protein in testicular cells of mice, rats, and camels
- Dynamic FRET-FLIM based screens of signal transduction pathways: a feasibility study
- Cyclic AMP Signaling
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