Epithelial-mesenchymal transition and its implications for fibrosis.
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Summary
This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.
- Type
- review
- Published
- 2003-12-15
- Cited by
- 2,650
- References
- 164
- Access
- Open access
- OpenAlex
- https://openalex.org/W2032942532
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11477421
Keywords
Epithelial–mesenchymal transition, Fibrosis, Mesenchymal stem cell, Context (archaeology), Biology
References
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- Pattern formation in skin development.
- Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.
- Possible mechanisms of renal fibrosis.
- Role of fibroblast activation in inducing interstitial fibrosis.
- Rodent models of nephropathy associated with type II diabetes.
- Subpopulations of rat lung fibroblasts with different amounts of type I and type III collagen mRNAs.
- Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
- Transcriptional regulation during somitogenesis.
- Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation.
- Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells.
- Neural crest development: the interplay between morphogenesis and cell differentiation.
- Molecular basis of transdifferentiation of pancreas to liver
- Organogenesis: Molecular Mechanisms Of Tubulogenesis
- Ras and Rho GTPases: a family reunion.
- A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.
- Epithelial Cell Plasticity in Development and Tumor Progression
- Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility.
Cited by
- Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?
- Epithelial vs myofibroblast differentiation in immortal rat lung cell lines—modulating effects of bleomycin
- Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved.
- Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation.
- Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
- Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.
- Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells.
- Protein kinase B/Akt activity is involved in renal TGF-β1-driven epithelial-mesenchymal transition in vitro and in vivo
- Blockade of endogenous tissue kallikrein aggravates renal injury by enhancing oxidative stress and inhibiting matrix degradation.
- Disparate Companions: Tissue Engineering Meets Cancer Research
- TGF-beta signaling and the renal tubular epithelial cell: too much, too little, and just right.
- Novel aspects of renal tubulointerstitial fibrosis
- Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition
- Soluble TNF-α Receptor I Encoded on Plasmid Vector and Its Application in Experimental Gene Therapy of Radiation-Induced Lung Fibrosis
- Therapeutic application of stem cells in gastroenterology: an up-date.
- Inhibition of Fibroblast Growth by Notch1 Signaling Is Mediated by Induction of Wnt11-Dependent WISP-1
- miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells
- Microenvironment-induced myofibroblast-like conversion of engrafted keratinocytes
- IGF2 expression and β-catenin levels are increased in Frozen Shoulder Syndrome.
- The Network of Epithelial-mesenchymal transition: potential new targets for tumor resistance
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