Inhibition of Fibroblast Growth by Notch1 Signaling Is Mediated by Induction of Wnt11-Dependent WISP-1
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Summary
Findings indicated that inhibition of fibroblast proliferation by Notch pathway activation is mediated, at least in part, through regulating Wnt1-independent, but Wnt11-dependent WISP-1 expression.
- Type
- article
- Published
- 2012-06-08
- Cited by
- 23
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W22715413
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15376744
Keywords
Physics, Particle (ecology), Astrophysics, Astronomy, Geology
References
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- Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues
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- Downregulation of CCN3 expression as a potential mechanism for melanoma progression
- Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction.
- Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells
- The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway*
- Molecular cloning and characterization of human WNT11.
- Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1
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- Tissue repair and the dynamics of the extracellular matrix.
- Analysis of Wnt Gene Expression in Prostate Cancer
- Matrix metalloproteinases in tumor-host cell communication.
Cited by
- Intracellular Notch1 Signaling in Cancer‐Associated Fibroblasts Dictates the Plasticity and Stemness of Melanoma Stem/Initiating Cells
- Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma
- The Capsaicin Receptor TRPV1 as a Novel Modulator of Neural Precursor Cell Proliferation
- The CCN family acting throughout the body: recent research developments
- Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells
- Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion
- Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells.
- Notch1—WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis
- Insights on the function of MyT1L in Ascl1 mediated neuronal reprogramming
- Dual effect of WISP-1 in diverse pathological processes
- Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury
- Notch Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling
- Notch signaling regulates cell density-dependent apoptosis of NIH 3T3 through an IL-6/STAT3 dependent mechanism
- Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.
- Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds
- Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity
- Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments
- Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation
- Myofibroblasts
- Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast proliferation by regulating the WWP2/Notch1 axis.