X-ray structure of a voltage-dependent K+ channel
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Summary
The structure of KvAP, a voltage-dependent K+ channel from Aeropyrum pernix, is presented and a crystal structure of the full-length channel at a resolution of 3.2 Å is determined, which suggests that the voltage-sensor paddles move in response to membrane voltage changes, carrying their positive charge across the membrane.
- Type
- article
- Published
- 2003-05-01
- Cited by
- 1,775
- References
- 44
- OpenAlex
- https://openalex.org/W2032734987
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4347957
Keywords
Gating, Ion channel, Voltage, Ion, Crystallography
References
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- 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten.
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- Voltage Sensor Movements
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- Contribution of the S4 segment to gating charge in the Shaker K+ channel.
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- The size of gating charge in wild-type and mutant Shaker potassium channels.
- Improved methods for building protein models in electron density maps and the location of errors in these models.
Cited by
- Stirring up controversy with a voltage sensor paddle.
- Binding of κ-Conotoxin PVIIA to Shaker K+ Channels Reveals Different K+ and Rb+ Occupancies within the Ion Channel Pore
- Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human β-tryptase
- Microbial K+ Channels
- Transmembrane S1 mutations in CNGA3 from achromatopsia 2 patients cause loss of function and impaired cellular trafficking of the cone CNG channel.
- Sodium channel mutations in epilepsy and other neurological disorders.
- Mechanisms of valence selectivity in biological ion channels
- Role of water molecules in the KcsA protein channel by molecular dynamics calculations.
- Gating prokaryotic mechanosensitive channels
- Has the code for protein translocation been broken?
- A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1.
- Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents
- Formation of Transmembrane Helices In Vivo—Is Hydrophobicity All that Matters?
- Sodium channels: ionic model of slow inactivation and state-dependent drug binding.
- Conformational dynamics of the KcsA potassium channel governs gating properties
- Is the mobility of the pore walls and water molecules in the selectivity filter of KcsA channel functionally important?
- Electroelastic coupling between membrane surface fluctuations and membrane-embedded charges: continuum multidielectric treatment.
- Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels*
- Modeling of voltage-gated ion channels
- On the estimation of cooperativity in ion channel kinetics: activation free energy and kinetic mechanism of Shaker K+ channel.
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