K-ras mutations and HLA-DR expression in large bowel adenomas.
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Summary
Coexpression of K-ras mutations and HLA-DR was found significantly more frequently in large and highly dysplastic adenomas, although two-way analysis of variance showing size and grade of dysplasia to be the most important variable.
- Type
- article
- Published
- 1996-07-01
- Cited by
- 37
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2028767282
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9118030
Keywords
Dysplasia, Adenoma, Point mutation, HLA-DR, Carcinogenesis
References
- Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique.
- Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification.
- Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.
- Molecular determinants of dysplasia in colorectal lesions.
- Loss of colonic HLA antigens in familial adenomatous polyposis.
- Mutations in c-K-ras 2 gene codon 12 during colorectal tumorigenesis in familial adenomatous polyposis.
- The clonal evolution of tumor cell populations.
- Loss of HLA‐A,B,C and de novo expression of HLA‐D in colorectal cancer
- Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
- Class II HLA antigen expression in familial polyposis coli is related to the degree of dysplasia.
- Expression of HLA‐D sub‐region products on human colorectal carcinoma
- Is heterogeneous expression of HLA-dr antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas?
- K‐ras activation in colorectal tumors from patients with familial polyposis coli
- Frequency of abnormal expression of HLA‐A,B,C and HLA‐DR molecules, invariant chain, and LFA‐3 (CD58) in colorectal carcinoma and its impact on tumor recurrence
- Heterogeneous epithelial expression of class II (HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis.
- Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
- Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in tubular and villous large-bowel adenomas with different grades of dysplasia.
- p21‐ras‐peptide‐specific T‐cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp)
- Expression of histocompatibility antigens and characterization of the lymphocyte infiltrate in hyperplastic polyps of the large bowel.
- Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins
Cited by
- Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics.
- Identification of differentially expressed genes in normal mucosa, adenoma and adenocarcinoma of colon by SSH.
- HLA-A3 restricted mutant ras specific cytotoxic T-lymphocytes induced by vaccination with T-helper epitopes
- ENHANCEMENT OF HLA-DR EXPRESSION IN HUMAN HEPATOCELLULAR CARCINOMA WITH INTERFERON
- Molecular mechanisms of human thyroid tumorigenesis
- HLA‐DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers
- Theoretical studies on the mechanism of radioprotection by Hoechst 33258 derivatives
- Antigen-processing machinery breakdown and tumor growth.
- Single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe for the detection of rare mutations
- Molecular changes in the Ki‐ras and APC genes in colorectal adenomas and carcinomas arising in the same patient
- Mutation analysis of K‐ras‐2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride
- K-ras mutations and prognosis in large-bowel carcinomas.
- Intradermal ras peptide vaccination with granulocyte‐macrophage colony‐stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
- Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe
- Real-Time Bidirectional Pyrophosphorolysis-Activated Polymerization for Quantitative Detection of Somatic Mutations
- Molecular staging of colorectal cancer
- A Relationship between K-ras Gene Mutations and Some Clinical and Histologic Variables in Patients with Primary Colorectal Carcinoma
- Different genetic pathways to proximal and distal colorectal cancer influenced by sex‐related factors
- Trends in the development of radioprotective agents.
- In vivo radioprotection of mouse brain endothelial cells by Hoechst 33342.
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