5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
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Summary
The mapped 5-hmC genome-wide in mouse hippocampus and cerebellum at three different ages allowed us to assess its stability and dynamic regulation during postnatal neurodevelopment through adulthood, and found developmentally programmed acquisition of 5-HMC in neuronal cells.
- Type
- article
- Published
- 2011-10-30
- Cited by
- 825
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1990689143
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12696575
Keywords
Epigenetics, DNA methylation, Rett syndrome, MECP2, Epigenomics
References
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- Transposable elements and the evolution of regulatory networks
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- Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation
Cited by
- Epigenetic Mechanisms of Depression and Antidepressants Action
- An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy.
- Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.
- Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis
- Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2).
- Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.
- DNA methylation and hydroxymethylation in stem cells
- TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus
- Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation
- Structural basis of MeCP2 distribution on non-CpG methylated and hydroxymethylated DNA
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- Epigenomics: sequencing the methylome.
- Environmental Alterations of Epigenetics Prior to the Birth
- Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
- Integrating early life experience, gene expression, brain development, and emergent phenotypes: unraveling the thread of nature via nurture.
- Epigenetics of aging.
- Cytosine modifications in myeloid malignancies.
- Mechanisms of Arsenic Toxicity in Humans: Interplay of Arsenic, Glutathione, and DNA Methylation in Bangladeshi Adults
- Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
- Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma
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