The human type II procollagen gene: identification of an additional protein-coding domain and location of potential regulatory sequences in the promoter and first intron.
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Summary
A modified gene structure for the exons encoding the pro-alpha 1(II) collagen NH2-propeptide is presented and it is suggested that the functional sequences within the promoter may extend to at least 649 bp upstream from the start site of transcription.
- Type
- article
- Published
- 1990-09-01
- Cited by
- 61
- References
- 49
- OpenAlex
- https://openalex.org/W2023434589
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5780246
Keywords
Biology, Intron, Exon, Gene, Enhancer
References
- Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene.
- Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors.
- Organization of the human pro-alpha 2(I) collagen gene.
- Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens.
- Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts.
- Characterization of the promoter for the alpha 1 (IV) collagen gene. DNA sequences within the first intron enhance transcription.
- Structure and sequence of the chicken type II procollagen gene. Characterization of the region encoding the carboxyl-terminal telopeptide and propeptide.
- Inhibiting effect of procollagen peptides on collagen biosynthesis in fibroblast cultures.
- Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA.
- Isolation and characterization of a cDNA clone for the amino-terminal portion of the pro-alpha 1(II) chain of cartilage collagen.
- Evidence for pretranslational regulation of collagen synthesis by procollagen propeptides.
- DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription.
- Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes.
- Identification of genomic DNA coding for chicken type II procollagen.
- Quantitative analysis of collagen expression in embryonic chick chondrocytes having different developmental fates.
- Structure of the promoter of the rat type II procollagen gene.
- Enhanced gene expression by the poly(dT-dG).poly(dC-dA) sequence
- Collagen expression in embryonic chicken chondrocytes treated with phorbol myristate acetate
- Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.
- Regulation of inducible and tissue-specific gene expression.
Cited by
- Tissue‐Specific and differential expression of alternatively spliced α1(II) collagen mRNAs in early human embryos
- Effets de perturbateurs endocriniens sur le développement du squelette
- The use of dynamic culture devices in articular cartilage tissue engineering.
- In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.
- A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon.
- An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes
- Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis
- Looping Mediated Interaction between the Promoter and 3′ UTR Regulates Type II Collagen Expression in Chondrocytes
- Prostaglandin E2 up‐regulates insulin‐like growth factor binding protein‐3 expression and synthesis in human articular chondrocytes by a c‐AMP‐independent pathway: Role of calcium and protein kinase A and C
- Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α
- Developmental expression of a type II collagen/β‐galactosidase fusion gene in transgenic mice
- Identification of a Minimum Enhancer Sequence for the Type II Collagen Gene Reveals Several Core Sequence Motifs in Common with the Link Protein Gene (*)
- Expression and localization of COL2A1 mRNA and type II collagen in human fetal cochlea.
- Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage.
- Egr-1 Mediates Transcriptional Repression of COL2A1Promoter Activity by Interleukin-1β*
- ESE‐1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes
- The 2.2-kb promoter of cartilage-derived retinoic acid-sensitive protein controls gene expression in cartilage and embryonic mammary buds of transgenic mice.
- A critical evaluation of specific aspects of joint development
- The Control of Expression of Type II Collagen: Relevance to Cartilage Disease
- Site-specific interaction of bone morphogenetic protein 2 with procollagen II.
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