Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.
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Summary
The concept of targeting protective prostaglandin receptors therapeutically after stroke is supported, as Expression of EP4 was robust in neurons and markedly induced in endothelial cells after ischemia-reperfusion, suggesting that neuronal and/or endothelial EP4 signaling imparts cerebroprotection.
- Type
- article
- Published
- 2011-11-01
- Cited by
- 86
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W1970184396
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24271329
Keywords
Ischemia, Agonist, Medicine, Prostaglandin E2 receptor, Receptor
References
- Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
- Blood flow-dependent functional recovery in a rat model of focal cerebral ischemia.
- Fetal immunization of baboons induces a fetal-specific antibody response
- Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice
- Developmental regulation of endothelial nitric oxide synthase in cerebral vessels of newborn pig by prostaglandin E(2).
- Prostaglandin D2 mediates neuronal protection via the DP1 receptor
- Estrogen Receptor Activation of Phosphoinositide-3 Kinase, Akt, and Nitric Oxide Signaling in Cerebral Blood Vessels: Rapid and Long-Term Effects
- Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine
- Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion
- Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system.
- Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity
- Emerging roles of PGE2 receptors in models of neurological disease
- EP4 prostanoid receptor‐mediated vasodilatation of human middle cerebral arteries
- Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice.
- Simvastatin Acutely Reduces Myocardial Reperfusion Injury In Vivo by Activating the Phosphatidylinositide 3-Kinase/Akt Pathway
- Activation of Akt/Protein Kinase B Contributes to Induction of Ischemic Tolerance in the CA1 Subfield of Gerbil Hippocampus
- PIKKing on PKB: regulation of PKB activity by phosphorylation.
- Isolation, characterization, and long-term cultivation of porcine and murine cerebral capillary endothelial cells.
- COX-2 inhibitors and cardiovascular risk.
- Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2
Cited by
- Examining the potential of PGE₂ receptor EP₄ as a neuroprotective target following ischaemic injury
- The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity
- Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats.
- Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer’s disease
- Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System
- PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice
- Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6
- The Syndecan-4/Protein Kinase Cα Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo*
- Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking.
- From gene variants to novel therapies. Is the prostaglandin e2 pathway in primary graft dysfunction ready for prime time?
- E-type prostanoid receptor 4 (EP4) in disease and therapy
- The immunology of neurodegeneration.
- Prostaglandin E2-induced IL-23p19 Subunit Is Regulated by cAMP-responsive Element-binding Protein and C/AATT Enhancer-binding Protein β in Bone Marrow-derived Dendritic Cells*
- Prostaglandin modulates TLR3-induced cytokine expression in human astroglioma cells.
- Post-ischemic inflammation regulates neural damage and protection
- Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia
- Neuroprotection mediated by the EP₄ receptor avoids the detrimental side effects of COX-2 inhibitors following ischaemic injury.
- Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling
- Protection by vascular prostaglandin E2 signaling in hypoxic ischemic encephalopathy
- G-Protein–Coupled Receptor 91 and Succinate Are Key Contributors in Neonatal Postcerebral Hypoxia-Ischemia Recovery
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