Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

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Summary

The apparent stochastic expression pattern of genes within the casein locus, the lower mRNA levels compared with mammary gland cells in conjunction with frequent coexpression of insulin in single mTECs clearly delineates the molecular mechanism(s) of promiscuous gene expression from cell lineage-specific gene control.

Type
article
Published
2008-01-15
Cited by
210
References
43
Access
Open access

Keywords

Biology, Gene expression, Gene, Regulation of gene expression, Cell fate determination

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