Mammalian RNA polymerase II core promoters: insights from genome-wide studies
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Summary
This work has shown that most mammalian genes do not conform to the simple model in which a TATA box directs transcription from a single defined nucleotide position, and alternative promoter usage generates diversity and complexity in the mammalian transcriptome and proteome.
- Type
- review
- Published
- 2007-06-01
- Cited by
- 566
- References
- 115
- OpenAlex
- https://openalex.org/W2019462186
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14939437
Keywords
Promoter, Biology, RNA polymerase II, Transcription factor II D, Genetics
References
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- Replication and transcription: Shaping the landscape of the genome
- Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
- Applied bioinformatics for the identification of regulatory elements
- Highly parallel genomic assays
- Diverse transcriptional initiation revealed by fine, large‐scale mapping of mRNA start sites
Cited by
- Functional analysis of human enhancers using the zebrafish embryo
- Translational control of gene expression from transcripts to transcriptomes.
- Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis.
- Systematic Clustering of Transcription Start Site Landscapes
- Transcription regulation at the core: similarities among bacterial, archaeal, and eukaryotic RNA polymerases.
- The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
- TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossina morsitans morsitans) vector of Trypanosomiasis
- Promoter Architecture and Sex-Specific Gene Expression in Daphnia pulex
- Differential context-specific impact of individual core promoter elements on transcriptional dynamics
- Control of human gene expression: High abundance of divergent transcription in genes containing both INR and BRE elements in the core promoter
- The spatial and temporal regulatory code of transcription initiation in Drosophila melanogaster
- Bioinformatic methods for eukaryotic RNA-Seq-based promoter identification
- Role of MAPK and NF-κB signalling pathways in the regulation of the human GM-CSF gene in normal and leukaemic blood cells
- Role and regulatory mechanisms of heat shock factor 2
- Mutation analysis of the promoter region of CYBRD1, HFE, LTF, HAMP and SLC40A1 in a Tuberculosis cohort
- Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome.
- Genome-Wide Studies of Transcriptional Regulation in Human Liver Cells by High-throughput Sequencing
- Regulatory regions in DNA: promoters, enhancers, silencers, and insulators.
- Chromosome-wide analysis of protein binding and modifications
- Genome-wide analysis of transcription initiation and promoter architecture in eukaryotes
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