Age-dependent excision repair of damaged thymine from γ-irradiated DNA by isolated nuclei from human fibroblasts
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Summary
It is reported that isolated nuclei or nuclear sonicates from senescent diploid human lung fibroblasts WI–38 have lost their ability to excise from DNA thymine damaged by γ rays.
- Type
- article
- Published
- 1975-04-03
- Cited by
- 70
- References
- 21
- OpenAlex
- https://openalex.org/W1970732673
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4280871
Keywords
WI-38, DNA repair, DNA, DNA damage, Biology
References
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- Current Topics in Radiation Research
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- Tolerance of Sk-incompatibte Skin Grafts
- Altered Enzymes in Ageing Human Fibroblasts
- Premature ageing and occurrance of altered enzyme in Werner's syndrome fibroblasts
- Ageing of Clones of Mammalian Cells
- The serial cultivation of human diploid cell strains.
- Excision of damaged thymine residues from gamma-irradiated poly(dA-dT) by crude extracts of Escherichia coli.
- Determination of base sequence in nucleic acids with the electron microscope. V. The thymine-specific reactions of osmium tetroxide with deoxyribonucleic acid and its components.
- A SIMPLE AND RAPID METHOD FOR THE ISOLATION OF ENZYMATICALLY ACTIVE HELA CELL NUCLEI
- Changes of enzymic activities in human diploid cell line WI-38 at various passages.
- Repair of x-ray damage in aging WI-38 cells.
- The maintenance of the accuracy of protein synthesis and its relevance to ageing.
- Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.
- Letter: Ultraviolet-induced repair replication in aging diploid human cells (WI-38).
- DNA-degradation and excision repair in gamma-irradiated Chinese hamster ovary cells.
Cited by
- Radiation survival of vascular smooth muscle cells as a function of age.
- In vitro aging. Cytogenetic comparison of diploid human fibroblast and epithelioid cell lines.
- Aging and sister chromatid exchange. II. The effect of the in vitro passage level of human fetal lung fibroblasts on baseline and mutagen-induced sister chromatid exchange frequencies.
- Repair of H2O2-induced DNA damage in bovine lens epithelial cell cultures.
- Reduced 5-hydroxymethyluracil-DNA glycosylase activity in Werner's syndrome cells.
- Testing the commitment theory of cellular aging.
- Changes in DNA polymerases alpha, beta, and gamma during the replicative life span of cultured human fibroblasts.
- Production and excision of thymine damage in the DNA of mammalian cells exposed to high-LET radiations.
- Levels of uracil DNA glycosylase and AP endonuclease in murine B- and T-lymphocytes do not change with age.
- Increase in abundance of a transcript hybridizing to elongation factor I alpha during cellular senescence and quiescence.
- Repair of x-ray-induced DNA damage in aging human diploid cells.
- Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay.
- Chromosome changes during the in vitro ageing of MRC-5 human fibroblasts.
- DNA repair deficiencies and cellular senescence are unrelated in xeroderma pigmentosum cell lines.
- Excision of ultraviolet and gamma ray products of the 5,6-dihydroxy-dihydrothymine type by nuclear preperations of xeroderma pigmentosum cells.
- Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation.
- Correlation of DNA repair synthesis with ageing in mice, evidenced by quantitative autoradiography.
- Normal DNA strand rejoining and absence of DNA crosslinking in progeroid and aging human cells.
- Glycosylases that excise modified DNA pyrimidines in young and senescent human WI-38 fibroblasts.
- Newly synthesised DNA in ageing human cells in culture treated with 4-nitroquinoline-1-oxide.
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