Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.
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Summary
Mice transgenic for a T cell receptor specific for the I-Au-restricted N-terminal peptide of myelin basic protein MBP Ac1-9 show maximal up-regulation of both CD28 and CTLA-4 2 days after peptide administration, and the implications for immune regulation are discussed.
- Type
- article
- Published
- 1999-05-01
- Cited by
- 175
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W10330272
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15865716
Keywords
Portfolio, Notice, Combinatorics, Capital (architecture), Mathematics
References
- Quantitative Analysis of Peptides from Myelin Basic Protein Binding to the MHC Class II Protein, I-Au, Which Confers Susceptibility to Experimental Allergic Encephalomyelitis
- CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation.
- Identification and distribution of the costimulatory receptor CD28 in the mouse.
- Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
- OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037]
- CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.
- CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.
- Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail (*)
- Peripheral deletion of antigen-reactive T cells in oral tolerance
- Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
- The emerging role of CTLA-4 as an immune attenuator.
- Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin
- Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy.
- B7-mediated costimulation can either provoke or prevent clinical manifestations of experimental allergic encephalomyelitis
- Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
- T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis
- B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
- Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
- CTLA-4 can function as a negative regulator of T cell activation.
- Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer.
Cited by
- Differential production of inflammatory chemokines by murine dendritic cell subsets.
- Fate of Chlamydophila pneumoniae in human monocyte-derived dendritic cells: long lasting infection.
- Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants
- Helicobacter pylori Inhibits Dendritic Cell Maturation via Interleukin-10-Mediated Activation of the Signal Transducer and Activator of Transcription 3 Pathway
- Molecular Events of Bacterial-Induced Maturation ofDendritic Cells
- Ethanol Exposure and Dendritic Cell Function
- Blood-borne cells involved in arterial repair upon experimental incision injury.
- Cell mediated immune response.
- Signals required for the induction of antigen-based therapeutic tolerance
- RANTES-Induced Chemokine Cascade in Dendritic Cells1
- Chemokines and Dendritic Cell Traffic
- Glycosylation enhances functional stability of the chemotactic cytokine CCL2.
- Crosstalk Between PKA and Epac Regulates the Phenotypic Maturation and Function of Human Dendritic Cells
- Evaluation of the Function of Human Invariant NKT Cells from Cancer Patients Using α-Galactosylceramide-Loaded Murine Dendritic Cells1
- CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation
- Dendritic cell biology.
- Mechanisms of respiratory syncytial virus specific T cell activation
- Cytokine regulation of monocytic cell subsets in the peritoneal cavity
- Analysis of host-pathogen interactions in novel three dimensional surrogate infection models
- Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation1
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