Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Explore this paper's citation graph
Summary
This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
- Type
- review
- Published
- 2007-08-01
- Cited by
- 2,035
- References
- 314
- OpenAlex
- https://openalex.org/W2018076136
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33609069
Keywords
Peroxynitrite, Nitric oxide, Peroxynitrous acid, Chemistry, Superoxide
References
- Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
- Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
- Reaction of Peroxynitrite with Mn-Superoxide Dismutase
- Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration.
- Defenses against peroxynitrite: selenocompounds and flavonoids.
- Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols.
- Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice.
- Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients.
- Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid.
- Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression.
- Mitochondria, nitric oxide, and peroxynitrite.
- Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite.
- Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion.
- AEOL-10150 (Aeolus).
- Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration.
- Effect of R-(-)-Deprenyl and Harmaline on Dopamine- and Peroxynitrite-Induced Membrane Permeability Transition in Brain Mitochondria
- Nitric Oxide, Cell Signaling, and Gene Expression
- Neuroprotection from Delayed Postischemic Administration of a Metalloporphyrin Catalytic Antioxidant
- Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.
- Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis
Cited by
- Nitrocytochrome c: synthesis, purification, and functional studies.
- A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury.
- Upregulation of heme oxygenase-1 as a host mechanism for protection against nitric oxide-induced damage in human renal epithelial cells.
- Oxidative stress: a common factor in testicular dysfunction.
- Mechanism of and exquisite selectivity for O–O bond formation by the heme-dependent chlorite dismutase
- Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress
- A murine model of sepsis following smoke inhalation injury.
- Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability.
- PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
- Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation
- Role of peroxynitrite-modified biomolecules in the etiopathogenesis of systemic lupus erythematosus
- Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles.
- Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism
- Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin
- Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: a comparison with ebselen.
- Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair
- Caffeic Acid Phenethyl Ester (CAPE): Scavenger of Peroxynitrite In Vitro and in Sepsis Models
- Interplay between polymorphisms in the endothelial nitric oxide synthase (eNOS) gene and metabolic syndrome in determining the risk of ischemic stroke in Koreans.
- Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes
- The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
Related papers
- On the proton affinity of peroxynitrite and peroxynitrous acid
- [Superoxide, nitric oxide and peroxynitrite].
- Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels
- Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite
- Peroxynitrite Chemistry: Formation, Decomposition and Possible Deactivation Mechanisms by Thiols
- Peroxynitrite formed by simultaneous nitric oxide and superoxide generation causes cyclosporin-A-sensitive mitochondrial calcium efflux and depolarisation.
- Detection of certain peroxynitrite-induced DNA modifications.
- Detection of peroxynitrite in biological fluids.
- Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.