Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
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Summary
The hypothesis that peroxynitrite is an important modulator of cyclooxygenase activity in inflammatory cells is supported and it is established that superoxide anion serves as a biochemical link between NO and prostaglandin biosynthesis.
- Type
- article
- Published
- 1996-12-24
- Cited by
- 412
- References
- 57
- OpenAlex
- https://openalex.org/W8986765
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36029309
Keywords
Mesa, Computer science
References
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- Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
- NITRIC OXIDE ENHANCES PROSTAGLANDIN-H SYNTHASE-1 ACTIVITY BY A HEME-INDEPENDENT MECHANISM : EVIDENCE IMPLICATING NITROSOTHIOLS
Cited by
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- Arachidonic Acid Oxygenation by COX-1 and COX-2
- Superoxide in the Vascular System
- Role of nitric oxide in physiology and pathology of the gastrointestinal tract.
- Molecular Mechanisms of the Nitric Oxide Induced Vessel Wall Dysfunction in Sepsis
- Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis.
- Anti-inflammatory agents as cancer therapeutics.
- Denitration of peroxynitrite-treated proteins by ‘protein nitratases’ from rat brain and heart
- Structure, function and inhibition of cyclo-oxygenases.
- Chronic inflammation as inductor of pro-cancer microenvironment: Pathogenesis of dysregulated feedback control
- Modulation de la biodisponibilité du monoxyde d'azote (no) en physiopathologie vasculaire : intérêt des stocks mobilisables de no et des antioxydants naturels
- The Mechanisms of Neuroprotection by Melatonin in Cerebral Ischaemia Reperfusion
- Regulation of in vivo prostaglandin biosynthesis by glutathione.
- Vitamin E and enhancement of the immune response in the aged: cellular and molecular mechanisms.
- Effects of the SOD mimic nitroxide 3-carbamoyl-PROXYL on oxidative stress markers and endothelial dysfunction in streptozotocin-induced diabetic rats.
- Signaling and Redox Regulation by Nitric Oxide, Superoxide and Carbon Monoxide
- Cyclooxygenase expression in human diabetes
- Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury?
- Antioxidant and anti-inflammatory properties of curcumin.
- Ascaris haemoglobin is a nitric oxide-activated ‘deoxygenase’
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