Programmed cell death induced by ceramide.
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Summary
The effects of C2-ceramide on DNA fragmentation were prevented by the protein kinase C activator phorbol 12-myristate 13-acetate, which suggests the existence of two opposing intracellular pathways in the regulation of apoptosis.
- Type
- article
- Published
- 1993-03-19
- Cited by
- 1,811
- References
- 23
- OpenAlex
- https://openalex.org/W2017729786
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32461579
Keywords
Ceramide, Sphingolipid, Sphingomyelin, Apoptosis, DNA fragmentation
References
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- Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
- Prolonged activation of jun and collagenase genes by tumour necrosis factor-α
- Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.
Cited by
- A study of changes in protein expression in the membranes of cells undergoing apoptosis
- Sepsis-induced erythrocytes apoptosis
- Phospholipase D, perméabilité endothéliale, et apoptose TNFα dépendante
- Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease).
- The Dimeric and Catalytic Subunit Forms of Protein Phosphatase 2A from Rat Brain Are Stimulated by C2-Ceramide (*)
- Role for Ceramide in Cell Cycle Arrest (*)
- Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine
- Modulation of Major Histocompatibility Complex Class I Genes by Interferon‐γ and Ganglioside GT1b in Astrocytes: Involvement of Protein Tyrosine Phosphatases
- Signal transduction pathways in apoptosis.
- Ceramide Inhibits Antigen Uptake and Presentation by Dendritic Cells
- Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
- Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells*
- Signal transduction through MAP kinase cascades.
- The role of sphingolipids in the process of signal transduction.
- Interferon-gamma-induced differentiation and apoptosis of HT29 cells: dissociation of (glucosyl)ceramide signaling.
- Mechanisms of ceramide-mediated apoptosis.
- Nitric Oxide Donors Induce Stress Signaling via Ceramide Formation in Rat Renal Mesangial Cells*
- Fas/CD95/Apo-I activates the acidic sphingomyelinase via Caspases
- Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis
- Distinct effects of ceramide‐generating pathways in prostate adenocarcinoma cells
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