Induction of programmed cell death and immunosuppression by exogenous sphingolipids are separate processes.
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Summary
It is concluded that exogenous sphingolipids cause inhibition of lymphoproliferation and PCD by two separate and distinct mechanisms of action.
- Type
- article
- Published
- 1996-10-01
- Cited by
- 17
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2022224202
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29427165
Keywords
Ceramide, Sphingolipid, Sphingosine, Programmed cell death, Lipid signaling
References
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- Human tumor gangliosides inhibit murine immune responses in vivo.
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- Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.
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- Inhibition of the lectin-induced mitogenic response of thymocytes by glycolipids.
- Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.
- Immunosuppression by human gangliosides. II. Carbohydrate structure and inhibition of human NK activity.
- Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation.
- Gangliosides induce selective modulation of CD4 from helper T lymphocytes.
- Regulation of lymphocyte responses by human gangliosides. I. Characteristics of inhibitory effects and the induction of impaired activation.
- Induction of apoptotic DNA fragmentation and cell death by natural ceramide
- The glomerular permeability determined by dextran clearance using Sephadex gel filtration.
- Programmed cell death of T cells signaled by the T cell receptor and the alpha 3 domain of class I MHC.
- Shedding of human neuroblastoma gangliosides.
- Inhibition of DNA Synthesis in C6 Glioma Cells Following Cellular Incorporation of GM1 Ganglioside and Choleragenoid Exposure
- Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin
- Promotion of Neuritogenesis in Mouse Neuroblastoma Cells by Exogenous Gangliosides. Relationship Between the Effect and the Cell Association of Ganglioside GM1
- A simple and novel method for tritium labeling of gangliosides and other sphingolipids.
- Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
Cited by
- Mechanisms of tumor evasion from the immune response.
- Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function.
- Induction of apoptosis in bone marrow cells by gangliosides produced by a T cell lymphoma.
- Gangliosides derived from a T cell lymphoma inhibit bone marrow cell proliferation and differentiation.
- Associative and predictive biomarkers of dementia in HIV-1–infected patients
- Ganglioside GD1a enhances VEGF-induced endothelial cell proliferation and migration.
- Glucosylceramide synthase inhibition enhances vincristine‐induced cytotoxicity
- Methods for the synthesis of tritium-labelled fatty acids and their derivatives, oxylipins and steroids
- A Novel Mechanism of CD4 Down-modulation Induced by Monosialoganglioside GM3
- Bioeffector Sphingolipids as Stimulators of Cell Growth and Survival
- Different mechanisms are involved in apoptosis induced by melanoma gangliosides on human monocyte-derived dendritic cells
- Bispecific antibodies for treatment of cancer in experimental animal models and man.
- Gangliosides regulate tumor cell adhesion to collagen
- 3'-sialyllactose neoglycoconjugates are not able to provide an immunological response against N-acetyl GM3 ganglioside in mice and chickens
- Sphingolipids: Mechanism-Based Inhibitors of Carcinogenesis Produced by Animals, Plants, and Other Organisms
- Brain-Metastasis Associated Genes
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