Studies of enzymes in mitochondrial DNA precursor synthesis
Explore this paper's citation graph
Summary
The potential mechanism underlying pyrimidine nucleoside analogs-associated mitochondrial toxicities was investigated, and it was found that thymidine analogs had opposite effects on dThd and dCyd phosphorylation and thus can inhibit dThD salvage, leading to imbalanced dTTP and dCTP pools.
- Type
- dissertation
- Published
- 2013-09-01
- Cited by
- 0
- References
- 224
- Access
- Open access
- OpenAlex
- https://openalex.org/W146070783
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83135636
Keywords
Mitochondrial DNA, Thymidine kinase, Nucleotide salvage, Deoxyguanosine, Mitochondrion
References
- Mammalian catalase: a venerable enzyme with new mysteries.
- Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options
- Uridine Abrogates Mitochondrial Toxicity Related to Nucleoside Analogue Reverse Transcriptase Inhibitors in Hepg2 Cells
- Combinations of nucleoside/nucleotide analogues for HIV therapy.
- Contribution of Mitochondrial Dysfunction and Oxidative Stress to Cellular Premature Senescence Induced by Antiretroviral Thymidine Analogues
- mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.
- Uridine Supplementation for the treatment of Antiretroviral Therapy-Associated Lipoatrophy: A Randomized, Double-Blind, Placebo-Controlled Trial
- Recent Advances in Nucleosides: Chemistry and Chemotherapy
- [44] Glutathione peroxidase
- Noncirrhotic portal hypertension associated with didanosine: a case report and literature review.
- 3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion.
- Cell cycle regulation of deoxycytidine kinase
- Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides.
- 2 cloning and expression of mouse deoxycytidine kinase. Pure recombinant mouse and human enzymes show differences in substrate specificity.
- Molecular and cellular aspects of thiol-disulfide exchange.
- Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage
- Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
- Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions
- Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity
- Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
Cited by
No citing papers recorded for this paper.
Related papers
- Studies of Enzymes in Mitochondrial DNA Precursor Synthesis-Regulatory Mechanisms for Human Thymidine Kinase 2 and Deoxyguanosine Kinase
- The Kinetic Effects on Thymidine Kinase 2 by Enzyme-Bound dTTP May Explain the Mitochondrial Side Effects of Antiviral Thymidine Analogs
- Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.
- Inhibition of mitochondrial thymidine kinase (TK-2) and related enzymes by N-1-substituted thymine derivatives
- Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs.
- Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase
- ChemInform Abstract: Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors.
- Activation of guanine-β-D-arabinofuranoside and deoxyguanosine to triphosphates by a common pathway blocks T lymphoblasts at different checkpoints.
- 2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis.