Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.
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Summary
Together the hMR and hGR provide unexpected functional diversity in which hormone-binding properties, target gene interactions, and patterns of tissue-specific expression may be used in a combinatorial fashion to achieve complex physiologic control.
- Type
- article
- Published
- 1987-07-17
- Cited by
- 1,869
- References
- 45
- OpenAlex
- https://openalex.org/W2015497140
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43461675
Keywords
Glucocorticoid receptor, Mineralocorticoid receptor, Mineralocorticoid, Biology, Receptor
References
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- Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor
- The c-erb-A protein is a high-affinity receptor for thyroid hormone
- Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement
- Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.
- Expression of an immunoglobulin heavy chain gene transfected into lymphocytes.
- Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA.
- Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product
- Primary structure and expression of a functional human glucocorticoid receptor cDNA
- Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.
- A comprehensive set of sequence analysis programs for the VAX
- The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.
- The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus
Cited by
- Steroid hormone receptors.
- Central 6-hydroxydopamine lesions decrease mineralocorticoid, but not glucocorticoid receptor gene expression in the rat hippocampus.
- Steroid modulation of the expression of growth factors and oncogenes in breast cancer.
- Tissue localization of 11β-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor
- Two point mutations in the hormone-binding domain of the mouse glucocorticoid receptor that dramatically reduce its function.
- Expression of the Xenopus laevis mineralocorticoid receptor during metamorphosis.
- Cortisol to cortisone: glucocorticoid to mineralocorticoid.
- Genetic diseases of steroid metabolism.
- Putative nuclear localization signals (NLS) in protein transcription factors
- Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
- The androgen receptor: an overview.
- Novel aldosterone receptors: specificity-conferring mechanism at the level of the cell membrane.
- Monogenic forms of mineralocorticoid hypertension: insights into the pathogenesis of ‘essential’ hypertension?
- Antagonism in the human mineralocorticoid receptor
- Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism.
- A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action.
- The conserved residues of the ligand-binding domains of steroid receptors are located in the core of the molecules.
- The myosin binding protein is a novel mineralocorticoid receptor binding partner.
- A Nuclear Receptor Atlas: macrophage activation.
- Development of a panel of monoclonal antibodies against the mineralocorticoid receptor.
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