Postnatal handling alters glucocorticoid, but not mineralocorticoid messenger RNA expression in the hippocampus of adult rats.
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Summary
The finding that postnatal handling significantly increased glucocorticoid receptor mRNA in all hippocampal cell fields is consistent with the results of receptor binding studies showing that handling increases hippocampal glucocortex receptor, but not mineralocortioid receptor density.
- Type
- article
- Published
- 1994-10-01
- Cited by
- 121
- References
- 30
- OpenAlex
- https://openalex.org/W2165563122
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22203675
Keywords
Mineralocorticoid receptor, Glucocorticoid receptor, Glucocorticoid, Endocrinology, Internal medicine
References
- Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence
- The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis.
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- Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat.
- Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat.
- Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats.
- The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus.
- Plasma-Free Corticosteroid Response to Electric Shock in Rats Stimulated in Infancy
- In situ hybridization mapping of glucocorticoid receptor messenger ribonucleic acid in rat brain.
- Effect of neonatal handling on age-related impairments associated with the hippocampus.
- Thyroid hormones influence the development of hippocampal glucocorticoid receptors in the rat: a mechanism for the effects of postnatal handling on the development of the adrenocortical stress response.
- Basal ACTH, corticosterone and corticosterone-binding globulin levels over the diurnal cycle, and age-related changes in hippocampal type I and type II corticosteroid receptor binding capacity in young and aged, handled and nonhandled rats.
- Infantile experience and resistance to physiological stress.
- Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain.
- Effects of early experience on adrenocortical reactivity
- Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression.
- Postnatal development and environmental regulation of hippocampal glucocorticoid and mineralocorticoid receptors.
- Central 5,7‐Dihydroxytryptamine Lesions Decrease Hippocampal Glucocorticoid and Mineralocorticoid Receptor Messenger Ribonucleic Acid Expression
- The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis.
- Postnatal ontogeny of mineralocorticoid and glucocorticoid receptor gene expression in regions of the rat tel- and diencephalon.
Cited by
- A single dose of metyrapone caused long-term dysregulation of the hypothalamic-pituitary-adrenal axis in the rat.
- Influência da manipulação neonatal sobre alterações metabólicas e neuroquímicas induzidas pela exposição crônica à dieta palatável na vida adulta
- Glucocorticoid mechanisms of neonatal separation effects on adult learning and memory
- 2006 Curt P. Richter award winner: Social influences on stress responses and health.
- Physiologic programming of the fetus.
- Repeated Maternal Deprivation Alters Behavioral Pattern and Attenuates Prolactin Response to Mild Stressor in Adult Male Wistar Rats.
- Fetal Nutrition and Adult Disease: Programming of Chronic Disease through Fetal Exposure to Undernutrition
- Early environments and neurobehavioural programming : therapeutic actions of antidepressants : neurobehavioural programming during development
- Effects of prenatal dietary methyl donor deficiency on development and epigenetic mechanisms in offspring : studies in the rat
- Epigenetic programming by early‐life stress: Evidence from human populations
- The Role of Early Adverse Life Events in the Etiology of Depression and Posttraumatic Stress Disorder
- Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats.
- Hypothalamic-pituitary-adrenal axis function in pony foals after neonatal ACTH-induced glucocorticoid overexposure.
- Postnatal Handling Increases the Expression of cAMP-Inducible Transcription Factors in the Rat Hippocampus: The Effects of Thyroid Hormones and Serotonin
- Early Environmental Regulation of Glucocorticoid Feedback Sensitivity in Young Adult Monkeys
- Effects of neonatal handling on basal and stress-induced monoamine levels in the male and female rat brain.
- Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats.
- Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats.
- Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.
- Quality of Child-Parent Attachment Moderates the Impact of Antenatal Stress on Child Fearfulness
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