Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia.
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Summary
The results indicate that prodigiosin reduces gp91(phox) and iNOS expression possibly by impairing NF-κB activation, which compromises the activation of microglial and/or inflammatory cells, which then mediates prodigioin's protective effect in the MCAo/r mice.
- Type
- article
- Published
- 2011-11-15
- Cited by
- 41
- References
- 35
- OpenAlex
- https://openalex.org/W2014473872
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21881777
Keywords
Prodigiosin, Nitric oxide, Hypoxia (environmental), Nitric oxide synthase, Reactive oxygen species
References
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- Andrographolide Inhibits PI3K/AKT-Dependent NOX2 and iNOS Expression Protecting Mice against Hypoxia/Ischemia-Induced Oxidative Brain Injury
- Enhanced production of prodigiosin-like pigment from Serratia marcescens SMdeltaR by medium improvement and oil-supplementation strategies.
- Prodigiosin isolated from Hahella chejuensis suppresses lipopolysaccharide-induced NO production by inhibiting p38 MAPK, JNK and NF-kappaB activation in murine peritoneal macrophages.
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- Development of natural anti-tumor drugs by microorganisms.
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- The biosynthesis and regulation of bacterial prodiginines
- In vivo rapid reduction of alloantigen‐activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25‐C and concanamycin B
- Enhanced undecylprodigiosin production from Serratia marcescens SS-1 by medium formulation and amino-acid supplementation.
- Suppression of T cell stimulating function of allogeneic antigen presenting cells by prodigiosin 25-C.
- Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat.
Cited by
- 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke.
- A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma
- The inhibitory effect of mesenchymal stem cell on blood–brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6
- Fluorescent Molecular Peroxidation Products: A Prognostic Biomarker of Early Neurologic Deterioration After Thrombolysis
- Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines.
- Neurodegenerative Evidence in Mice Brains with Cecal Ligation and Puncture-Induced Sepsis: Preventive Effect of the Free Radical Scavenger Edaravone
- Natural Compounds as Modulators of NADPH Oxidases
- Effects and Mechanism of Action of Inducible Nitric Oxide Synthase on Apoptosis in a Rat Model of Cerebral Ischemia‐Reperfusion Injury
- Method parameters’ impact on mortality and variability in mouse stroke experiments: a meta-analysis
- Baicalein Attenuates Neurological Deficits and Preserves Blood–Brain Barrier Integrity in a Rat Model of Intracerebral Hemorrhage
- NADPH oxidase 2 does not contribute to early reperfusion-associated reactive oxygen species generation following transient focal cerebral ischemia
- N-stearoyltyrosine protects primary cortical neurons against oxygen-glucose deprivation-induced apoptosis through inhibiting anandamide inactivation system.
- Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1
- Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy
- Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin
- PG-Priming Enhances Doxorubicin Influx to Trigger Necrotic and Autophagic Cell Death in Oral Squamous Cell Carcinoma
- Bioactive Compound Prodigiosin in Vivo Affecting the Nutrient Metabolism of Weaned Rats
- Oxygen Radical Disease in the Newborn, Revisited: Oxidative Stress and Disease in the Newborn Period
- Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells
- Cytotoxic Effect of Prodigiosin, Natural Red Pigment, Isolated from Serratia marcescens UFPEDA 398
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