T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens.
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Summary
Prodigiosin was isolated from the culture broth of Serratia marcescens B-1231 and did not cause death in vitro to lymphocytes at effective concentrations and also did not show toxicity in vivo to lymphoid organs at effective dosages.
- Type
- article
- Published
- 1998-07-08
- Cited by
- 106
- References
- 20
- OpenAlex
- https://openalex.org/W2029741715
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21937449
Keywords
Prodigiosin, Serratia marcescens, Concanavalin A, In vivo, Lipopolysaccharide
References
- Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.
- Concanavalin A triggers T lymphocytes by directly interacting with their receptors for activation.
- Effects of FK-506 on the course of murine salmonellosis.
- Antimalarial Activity of Prodigiosin
- Effects of prodigiosin 25-C on cultured cell lines: its similarity to monovalent polyether ionophores and vacuolar type H(+)-ATPase inhibitors.
- Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus.
- Suppression of B cell activation by cyclosporin A, FK506 and rapamycin
- Principle of the bark of Phellodendron amurense to suppress the cellular immune response.
- Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2
- Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxic T cells.
- Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin: Diels-Alder reactions of heterocyclic azadienes and development of an effective palladium(II)-promoted 2,2'-bipyrrole coupling procedure
- 41-Demethylhomooligomycin B, a new immunosuppresant antibiotic from Streptomyces ostreogriseus.
- A novel method of screening for immunomodulating substances, establishment of an assay system and its application to culture broths of microorganisms.
- Facilitation of apoptosis by autologous serum and related immunosuppression in the splenocyte culture.
- Suppression of Alloantigen Presentation by Prodigiosin, a T Cell‐Specific Immunosuppressant
- Prodigiosin 25C: effect in in vitro models for T cell activation and T cell cycling and in vivo for rat heart allografts.
- Suppression of cytotoxic T cell induction in vivo by prodigiosin 25-C.
- New Immunosuppressive Drugs: Mechanistic Insights and Potential Therapeutic Advances
- Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.
- Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression.
Cited by
- Seeing red: the story of prodigiosin.
- Facultat de Medicina
- Characterization, DNA Binding and Cleavage Activities of New Prodigiosin and Tambjamine Analogues and Their Cu2+ and Zn 2+ Complexes
- Spray dried prodigiosin from Serratta Marcescens as a food colorant
- Caracterización y purificación de un principio activo de origen bacteriano con actividad antitumoral.
- Chemical, Toxicological, and Microbial Characterization of New Orleans Sediments Following Hurricane Katrina
- Prodigiosin production from Serratia marcescens strains obtained from farm soil
- The LuxR family protein SpnR functions as a negative regulator of N‐acylhomoserine lactone‐dependent quorum sensing in Serratia marcescens
- A Compound Inhibits Biofilm Formation of Staphylococcus aureus from Streptomyces.
- Natural products in soil microbe interactions and evolution.
- Efficient recombinant production of prodigiosin in Pseudomonas putida
- Influence of culture conditions and medium composition on the production of antibacterial compounds by marine Serratia sp. WPRA3
- Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines
- Prodigiosin from Vibrio sp. DSM 14379; A New UV-Protective Pigment
- Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin.
- Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells.
- Antimetastatic effect of prodigiosin through inhibition of tumor invasion.
- Antifungal activity of Serratia marcescens CFFSUR-B2 purified chitinolytic enzymes and prodigiosin against Mycosphaerella fijiensis, causal agent of black Sigatoka in banana (Musa spp.)
- Transcriptional Downregulator HexS Controlling Prodigiosin and Serrawettin W1 Biosynthesis in Serratia marcescens
- New immunosuppressive activity of dykellic acid.
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