Twenty-five Years of PTHrP Progress from Cancer Hormone to Multifunctional Cytokine
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Summary
Great strides have been made in understanding of PTHrP actions, yet years of exciting investigation and discovery are imminent, according to the American Society for Bone and Mineral Research.
- Type
- review
- Published
- 2012-05-01
- Cited by
- 168
- References
- 124
- Access
- Open access
- OpenAlex
- https://openalex.org/W2014047760
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7291778
Keywords
Intracrine, Paracrine signalling, Parathyroid hormone-related protein, Parathyroid hormone, Endocrine system
References
- Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.
- Parathyroid hormone-related protein promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis.
- Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
- Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms.
- Defining the roles of parathyroid hormone-related protein in normal physiology.
- The regulation of protein transport to the nucleus by phosphorylation.
- A rapid and selective vasodialtor effect of parathyroid hormone.
- A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
- Phosphorylation at the Cyclin-dependent Kinases Site (Thr85) of Parathyroid Hormone-related Protein Negatively Regulates Its Nuclear Localization*
- Some thoughts on the nature of ectopic parathyroid hormones.
- RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
- Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor.
- Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer.
- Direct evidence that PTHrP expression promotes prostate cancer progression in bone.
- Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions.
- An immunohistochemical investigation of the expression of parathyroid hormone receptors in rat cementoblasts.
- Parathyroid hormone-related protein is required for tooth eruption.
- Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation
- Proapoptotic effects of parathyroid hormone-related protein in type II pneumocytes.
- Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
Cited by
- PTHrP Expression in Human MDA-MB-231 Breast Cancer Cells Is Critical for Tumor Growth and Survival and Osteoblast Inhibition
- Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies
- Animal Models of Cancer-Associated Hypercalcemia
- Parathyroid Hormone-Like Hormone Induces Epithelial-to-Mesenchymal Transition of Intestinal Epithelial Cells by Activating the Runt-Related Transcription Factor 2.
- Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner
- The Influence of Primary Microenvironment on Prostate Cancer Osteoblastic Bone Lesion Development
- PTHrP attenuates osteoblast cell death and apoptosis induced by a novel class of anti-cancer agents
- Calcitonin Physiology, Saved by a Lysophospholipid
- Molecular Mechanisms Associated With PTHrP‐Induced Proliferation of Colon Cancer Cells
- The IRE1α-XBP1 Pathway Positively Regulates Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Expression and Is Involved in PTH-induced Osteoclastogenesis*
- Nanochannel array device operating through Prussian blue nanoparticles for sensitive label-free immunodetection of a cancer biomarker.
- Muscle–bone and fat–bone interactions in regulating bone mass: do PTH and PTHrP play any role?
- Conversations with pioneers in the bone field: T. John Martin
- Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development
- Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of β-Catenin activation of the DKK1 promoter in prostate cancer
- TGF-β Induces Degradation of PTHrP Through Ubiquitin-Proteasome System in Hepatocellular Carcinoma
- Developmental defects of enamel and dentine: challenges for basic science research and clinical management.
- Evolution of Parathyroid Hormone Receptor Family and Their Ligands in Vertebrate
- Activated Effects of Parathyroid Hormone-Related Protein on Human Hepatic Stellate Cells
- Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage
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