Parathyroid Hormone-Related Protein/Parathyroid Hormone Receptor 1 Signaling in Cancer and Metastasis
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Summary
A comprehensive review of the studies of the role of PTHrP/PTH1R in cancer progression and metastasis is conducted and the strengths and limitations of targeting P THrP or PTH1r in cancer therapy are highlighted.
- Type
- review
- Published
- 2023-03-26
- Cited by
- 13
- References
- 131
- Access
- Open access
- OpenAlex
- https://openalex.org/W4361008844
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:257786668
Keywords
Intracrine, Parathyroid hormone-related protein, Autocrine signalling, Paracrine signalling, Cancer research
References
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- Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer
- Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.
- Parathyroid hormone-related protein promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis.
- STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM: IV. The Effect of the Parathyroid Hormone
- The COOH‐terminus of parathyroid hormone‐related protein (PTHrP) interacts with β‐arrestin 1B 1
- Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe
- The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis (*)
- Novel Parathyroid Hormone (PTH) Antagonists That Bind to the Juxtamembrane Portion of the PTH/PTH-related Protein Receptor*
- Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor.
- Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin
- Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
- Direct evidence that PTHrP expression promotes prostate cancer progression in bone.
- Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases
- Gαq Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone*
- The Skeletal Response to Teriparatide Is Largely Independent of Age, Initial Bone Mineral Density, and Prevalent Vertebral Fractures in Postmenopausal Women With Osteoporosis
- Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development
- Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
- Parathyroid hormone-related protein production by breast cancers, improved survival, and reduced bone metastases.
- A Seven Day Continuous Infusion of PTH or PTHrP Suppresses Bone Formation and Uncouples Bone Turnover
Cited by
- Role of Parathyroid Hormone and Parathyroid Hormone-Related Protein in Protein-Energy Malnutrition.
- Combined signature of G protein-coupled receptors and tumor microenvironment provides a prognostic and therapeutic biomarker for skin cutaneous melanoma
- Colorectal cancer associated with parathyroid hormone-related protein (review)
- Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing
- The Impact of Non-bone Metastatic Cancer on Musculoskeletal Health
- Risk of Malignant Neoplasm in Patients with Primary Hyperparathyroidism: A Systematic Review and Meta-analysis
- Aggravation of atherosclerosis by parathyroid hormone access
- Genetic alterations and aberrant hormonal pathways in thymic epithelial tumors
- Parathyroid hormone–related protein is a therapeutic target in idiopathic pulmonary fibrosis
- Mechanisms, Management and Prognosis of Paraneoplastic Hypercalcemia in Penile Squamous Cell Carcinoma: A Structured Review
- Kidney disease and determinants of health as correlates to primary bone cancer: a cross-sectional US population-based study
- Elevated parathyroid hormone-related peptide serum levels were associated with breast cancer tumor progression
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