Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

Keywords

Notochord, Anatomy, Sonic hedgehog, Biology, Hedgehog

References

• Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and AgingE Serrelli — 2009
• Localisation of extracellular matrix components in the embryonic human notochord and axial mesenchyme.Werner Götz, R. Osmers, Rainer Herken — 1995
• Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts.David G. Wilkinson, M. Ángela Nieto — 1993
• Generalized lacZ expression with the ROSA26 Cre reporter strainPhilippe Soriano — 1999
• Histochemistry of the developing notochord, perichordal sheath and vertebrae in Danforth's short-tail (sd) and normal C57BL/6 mice.Laurie G. Paavola, Doris B. Wilson — 1980
• The development of fibrocartilage in the rat intervertebral discA. Rufai, Michael Benjamin, James R. Ralphs — 1995
• Ultrastructural aspects of the production of extracellular matrix components by the chick embryonic notochord in vitro.J. Camón, Eduard Degollada, Javier Verdú — 1990
• Quantitative Magnetic Resonance Imaging of Enzymatically Induced Degradation of the Nucleus Pulposus of Intervertebral DiscsJohn Antoniou, Fackson Mwale, Caroline N. Demers — 2006
• Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.Jianjian Zhu, Eiichiro Nakamura, Minh‐Thanh Nguyen — 2008
• Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular boneYukiko Maeda, Eiichiro Nakamura, Minh‐Thanh Nguyen — 2007
• Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.Xiaoyan M. Zhang, Miguel Ramalho‐Santos, Andrew P. McMahon — 2001
• The mouse bagpipe gene controls development of axial skeleton, skull, and spleen.Laura A. Lettice, Lorna A. Purdie, Geoffrey J. Carlson — 1999
• The Notochordal Cell in the Nucleus Pulposus: A Review in the Context of Tissue EngineeringChristopher Hunter, John R. Matyas, Neil A. Duncan — 2003
• Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionChin Chiang, Ying Litingtung, Eric Lee — 1996
• A critical role for sonic hedgehog signaling in the early expansion of the developing brainJoanne M. Britto, David Tannahill, Roger J. Keynes — 2002
• Molecular signaling in intervertebral disk developmentChristian P. DiPaola, James C. Farmer, Katia Manova — 2005
• Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling.L. Charles Murtaugh, Jay H. Chyung, Andrew B. Lassar — 1999
• Identification of Nucleus Pulposus Precursor Cells and Notochordal Remnants in the Mouse: Implications for Disk Degeneration and Chordoma FormationKyung‐Suk Choi, Martin J. Cohn, Brian D. Harfe — 2008
• Lumbar disc disorders and low-back pain: socioeconomic factors and consequences.Jeffrey N. Katz — 2006
• Hedgehog signaling in animal development: paradigms and principles.Philip W. Ingham, Andrew P. McMahon — 2001

Cited by

• The role of brachyury in the pathogenesis of chordomaN. Pillay — 2013
• Zebrafish models of cystic kidney disease related ciliopathiesRoslyn Simms — 2013
• Investigating the cell population of the adult human nucleus pulposusFrancesca E. Ludwinski — 2014
• Notochord development in Atlantic salmon (Salmo salar L.): exploring molecular pathways and putative mechanism of segmentationWang Shou — 2014
• Notochord to Nucleus Pulposus TransitionLisa Y. Lawson, Brian D. Harfe — 2015
• Diversity of intervertebral disc cells: phenotype and functionGirish Pattappa, Zhen Li, Marianna Peroglio — 2012
• The generation of vertebral segmental patterning in the chick embryoBiruntha Senthinathan, Catia Ferreira de Sousa, David Tannahill — 2012
• Defining the Phenotype of Young Healthy Nucleus Pulposus Cells: Recommendations of the Spine Research Interest Group at the 2014 Annual ORS MeetingMakarand V. Risbud, Zachary R. Schoepflin, Fackson Mwale — 2015
• Building the backbone: the development and evolution of vertebral patterningAngeleen Fleming, Marcia Gruppi Kishida, Charles B. Kimmel — 2015
• Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus PulposusChristophe Merceron, Laura Mangiavini, Alexander G. Robling — 2014
• Cell Signaling Pathways Related to Pain Receptors in the Degenerated DiskAkihiko Hiyama, Daisuke Sakai, Joji Mochida — 2013
• IS THE SPINAL MOTION SEGMENT A DIARTHRODIAL POLYAXIAL JOINT: WHAT A NICE NUCLEUS LIKE YOU DOING IN A JOINT LIKE THIS?Irving M. Shapiro, Edward J. Vresilovic, Makarand V. Risbud — 2011
• Investigating Microenvironmental Regulation of Human Chordoma Cell BehaviourPriya Patel, Courtney Brooks, Ayesh K. Seneviratne — 2014
• Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells In VitroJun Chen, Esther J. Lee, Liufang Jing — 2013
• In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome.Tracie Pennimpede, Judith Proske, Andrea König — 2012
• Mechanotransduction in intervertebral discsTsung‐Ting Tsai, Chao‐Min Cheng, Chien‐Fu Chen — 2014
• Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesodermAki Murashima, Hiroki Akita, Mika Okazawa — 2013
• Bmp2, Bmp4 and Bmp7 Are Co-Required in the Mouse AER for Normal Digit Patterning but Not Limb OutgrowthKyung Suk Choi, Chanmi Lee, Danielle M. Maatouk — 2012
• Intervertebral disc regeneration: a great challenge for tissue engineers.Pauline Colombier, Anne Camus, Laurent Lescaudron — 2014
• Key role for the transcriptional factor, osterix, in spine development.Sixu Chen, Jianquan Feng, Hua Zhang — 2014

Related papers

• From notochord to vertebral column: studies on Atlantic salmon (Salmo salar L.)Kari Nordvik — 2007
• The role of the notochord in vertebral column formationAngeleen Fleming, Roger J. Keynes, David Tannahill — 2001
• The role of the notochord in vertebral column formationAngeleen Fleming, Roger J. Keynes, David Tannahill — 2001
• The role of the somites and notochord in vertebral column developmentErin E. Ward, Susan E. Evans, Claudio D. Stern — 2015
• Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discsKyung‐Suk Choi, Chanmi Lee, Brian D. Harfe — 2012
• Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.Valeria Marigo, Randy L. Johnson, Andrea Vortkamp — 1996
• Endothelial cell response to Hedgehog ligands depends on their processingPierre-Louis Hollier, Candice Chapouly, Aïssata Diop — 2020
• Functions of Sonic Hedgehog in AngiogenesisRuijuan Xiu — 2005
• [Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas].Li Che, Jun Ren, Yan Yuan — 2008
• Regulation of patched by sonic hedgehog in the developing neural tube.Valeria Marigo, Clifford J. Tabin — 1996