Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria
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Summary
The depletion and functional inhibition of bcl-2 contributes to cardiac injury by increasing susceptibility to MPTP opening in high calcium environments and MOMP in the absence of calcium overload.
- Type
- article
- Published
- 2015-03-10
- Cited by
- 63
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013343698
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18105232
Keywords
MPTP, Mitochondrial permeability transition pore, Mitochondrion, Ischemia, Calcium
References
- Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle.
- Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria.
- Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice.
- Ischemic and anesthetic preconditioning reduces cytosolic [Ca2+] and improves Ca(2+) responses in intact hearts.
- Reversible Blockade of Electron Transport during Ischemia Protects Mitochondria and Decreases Myocardial Injury following Reperfusion
- Bcl-2 family members and apoptosis, taken to heart.
- Blockade of Electron Transport During Ischemia Preserves bcl-2 and Inhibits Opening of the Mitochondrial Permeability Transition Pore
- Biochemical differences between subsarcolemmal and interfibrillar mitochondria from rat cardiac muscle: effects of procedural manipulations.
- Cardioprotection by modulation of mitochondrial respiration during ischemia-reperfusion: role of apoptosis-inducing factor.
- Blockade of Electron Transport before Cardiac Ischemia with the Reversible Inhibitor Amobarbital Protects Rat Heart Mitochondria
- Resistance to Ca2+-induced opening of the permeability transition pore differs in mitochondria from glycolytic and oxidative muscles.
- Bcl-2 regulation of mitochondrial energetics.
- Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit heart: role of cardiolipin.
- Activation of mitochondrial u-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion
- The BCL-2 Family Reunion
- Bax regulates primary necrosis through mitochondrial dynamics
- Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.
- Mitochondria and cell death: outer membrane permeabilization and beyond
- Cytochrome c release from mitochondria proceeds by a two-step process
- Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III.
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- Heart mitochondria and calpain 1: Location, function, and targets.
- Melatonin and Ischemic Stroke: Mechanistic Roles and Action
- Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart
- ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling.
- Chronic heart failure: Ca2+, catabolism, and catastrophic cell death
- Mitochondria Related Pathway Is Essential for Polysaccharides Purified from Sparassis crispa Mediated Neuro-Protection against Glutamate-Induced Toxicity in Differentiated PC12 Cells
- Functional Implications of the spectrum of BCL2 mutations in Lymphoma.
- Silencing of astrocyte elevated gene‐1 inhibits proliferation and migration of melanoma cells and induces apoptosis
- Mechanistic Role of mPTP in Ischemia-Reperfusion Injury.
- Cardioprotective effect of the xanthones from Gentianella acuta against myocardial ischemia/reperfusion injury in isolated rat heart.
- Calcium signaling and cell cycle: Progression or death.
- Effects of Curcumin on Sperm Motility, Viability, Mitochondrial Activity and Plasma Membrane Integrity in Boar Semen
- Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion
- A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways
- COX6B1 relieves hypoxia/reoxygenation injury of neonatal rat cardiomyocytes by regulating mitochondrial function
- High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis
- Dynamic changes of mitochondrial function at different stages of myocardial injury in sepsis model rats
- Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling.
- Molecular Alterations and Effects of Acute Dehydroepiandrosterone Treatment Following Brief Bilateral Common Carotid Artery Occlusion: Relevance to Transient Ischemic Attack.
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