Control of protein synthesis and mRNA degradation by microRNAs.
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Summary
The function of microRNAs and the precise mechanism by which they suppress gene expression remain elusive and a better understanding of the mechanism should facilitate studies of their function.
- Type
- review
- Published
- 2008-04-01
- Cited by
- 274
- References
- 75
- OpenAlex
- https://openalex.org/W2013029756
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29888953
Keywords
Biology, microRNA, Argonaute, Regulation of gene expression, Gene expression
References
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- Human let-7a miRNA blocks protein production on actively translating polyribosomes
- Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation
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- Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
- Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
- Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies
- The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans.
- Disruption of GW bodies impairs mammalian RNA interference
- Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
- Identification of Human microRNA Targets From Isolated Argonaute Protein Complexes
- A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain
- MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
- Principles of MicroRNA–Target Recognition
- Localization-dependent oskar protein accumulation; control after the initiation of translation.
- P bodies and the control of mRNA translation and degradation.
- A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.
- Cytoplasmic foci are sites of mRNA decay in human cells
- microRNA target predictions in animals
- AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.
Cited by
- miR signatures and the role of miRs in acute myeloid leukaemia.
- The role of microRNAs during hepatitis C viral infection and liver regeneration
- Análise in silico de microRNA com perfis de expressão alterados no modelo animal de autismo induzido por exposição pré-natal ao ácido valpróico
- Microrna-302 as a redox sensitive regulator of ARID4a and CCL5
- The role of microRNAs in germline differentiation
- TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR‐573
- miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma.
- MicroRNAs play a role in human embryonic stem cell differentiation into endothelial cells
- Selenium-gene interactions involving microRNAs
- MicroRNA signature in response to nutrient restriction and re-feeding in fast skeletal muscle of grass carp (Ctenopharyngodon idella).
- Computational Methods for MicroRNA Target Prediction
- Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling
- Développement d'un vecteur lentiviral ciblant les astrocytes et mise en application dans l'étude des transporteurs au glutamate GLAST et GLT-1
- Novel approaches to the development and assessment of an ovine model of polycystic ovary syndrome
- Comparative Aspects of Molecular Mechanisms of Drug Resistance through ABC Transporters and Other Related Molecules in Canine Lymphoma
- Differentially Expressed MicroRNAs Act As Inhibitors of BDNF in Prefrontal Cortex - Implications for Schizophrenia: A Dissertation
- The network of P‐glycoprotein and microRNAs interactions
- Age-related changes in microRNA expression and pharmacogenes in human liver
- Computational methods for microRNA target prediction.
- Novel Anti-viral Strategies for Hepatitis C
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