Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes.
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Summary
It is shown that pRNA interacts with the target site of the transcription factor TTF-I, forming a DNA:RNA triplex that is specifically recognized by the DNA methyltransferase DNMT3b, suggesting that recruitment of DN MT3b by DNA: RNA triplexes may be a common and generally used pathway in epigenetic regulation.
- Type
- article
- Published
- 2010-10-15
- Cited by
- 500
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012589963
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25020415
Keywords
Biology, DNMT3B, DNA methylation, Genetics, RNA
References
- RNA meets chromatin.
- Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter.
- NoRC—a novel member of mammalian ISWI‐containing chromatin remodeling machines
- Trapped in action: direct visualization of DNA methyltransferase activity in living cells
- Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum.
- A Triplex-forming Sequence from the Human c-MYC Promoter Interferes with DNA Transcription*
- The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription
- The Genetic Signatures of Noncoding RNAs
- A transcription terminator located upstream of the mouse rDNA initiation site affects rRNA synthesis.
- Genetic regulatory mechanisms in the synthesis of proteins.
- Intergenic transcripts regulate the epigenetic state of rRNA genes.
- Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing
- The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription
- The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
- Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences.
- Characterization and quantification of triple helix formation in chromosomal DNA.
- Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription.
- RNA turnover and chromatin-dependent gene silencing
- Triplex-forming oligonucleotide target sequences in the human genome.
- The structure of NoRC‐associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus
Cited by
- Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis.
- Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes.
- Linking RNA biology to lncRNAs
- Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA
- Molecular basis for the autonomous promotion of cell proliferation by angiogenin
- Functional analysis of long noncoding RNAs in development and disease.
- Nucleolar epigenomics by dynamic molecular combing and nucleolar matrix analysis
- Statistical analysis of networks and biophysical systems of complex architecture
- Long non-coding RNAs in gastric cancer: versatile mechanisms and potential for clinical translation.
- Méthylation/déméthylation de l'ADN et expression du génome
- Comparative studies on elongation and termination of the three RNA polymerases from S. cerevisiae in vitro
- lncRNAs and microRNAs with a role in cancer development.
- Stressing out over long noncoding RNA
- Chromatin Remodelers: From Function to Dysfunction
- Mammalian epigenetic mechanisms
- Long noncoding RNA in hematopoiesis and immunity.
- RNAP‐II transcribes two small RNAs at the promoter and terminator regions of the RNAP‐I gene in Saccharomyces cerevisiae
- Characterization of non-coding RNAs in cancer
- Regulatory Roles of Noncoding RNA in Development and Disease
- Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
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