The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
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Summary
The findings suggest that the Gcn5p bromodomain may discriminate between different acetylated lysine residues depending on the context in which they are displayed.
- Type
- article
- Published
- 2000-11-15
- Cited by
- 555
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012317303
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45606027
Keywords
Biology, Bromodomain, Acetylation, Histone H4, Histone acetyltransferase
References
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- [27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.
- Structure and ligand of a histone acetyltransferase bromodomain
- brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2.
- Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide
- Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.
- Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.
- GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo.
- Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin.
- Improved R-factors for diffraction data analysis in macromolecular crystallography
- Structure of the regulatory domains of the Src-family tyrosine kinase Lck
- The transcriptional coactivators p300 and CBP are histone acetyltransferases.
- A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals
- Acetylation and chromosomal functions.
- The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins.
- The Gcn5 bromodomain co-ordinates nucleosome remodelling
- Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.
Cited by
- Crosstalk between the ER stress pathway and osmotic stress in S. cerevisiae
- Protein-protein interactions in signaling cascades
- HBXAP, a novel PHD-finger protein, possesses transcription repression activity.
- Targeted Recruitment of Rpd3 Histone Deacetylase Represses Transcription by Inhibiting Recruitment of Swi/Snf, SAGA, and TATA Binding Protein
- Organization of cell–regulatory systems through modular–protein–interaction domains
- The role of human bromodomains in chromatin biology and gene transcription
- Acetyllysine-binding and function of bromodomain-containing proteins in chromatin.
- dbPTM 3.0: an informative resource for investigating substrate site specificity and functional association of protein post-translational modifications
- Cell differentiation along multiple pathways accompanied by changes in histone acetylation status.
- Determination of histone acetylation status by chromatin immunoprecipitation.
- LES HISTONES DEACETYLASES DE TOXOPLASMA GONDII : IMPLICATION DANS LA PHYSIOLOGIE DES APICOMPLEXES ET EVALUATION EN TANT QUE NOUVELLES CIBLES THERAPEUTIQUES
- Histone modifications in cancer biology and prognosis.
- Interaction between the SAGA complex and chromatin regulates nucleosome acetylation and inducible gene transcription
- Characterising the MLL complex: epigenetic regulation of Hoxa genes
- The Role of the Double Bromodomain-Containing BET Genes During Mammalian Spermatogenesis
- The bromodomain proteins GTE9 and GTE11 associate with BT2-based E3 ligase complex and mediate responses to multiple signals in Arabidopsis thaliana
- Regulation of transcription by a dual modification mark at histone H3
- Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56.
- The nucleosome: from genomic organization to genomic regulation.
- Analysis of chromatin targeting modules in the chromatin remodelling enzyme NURF
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